Results 21 to 30 of about 300,590 (210)

1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation [PDF]

, 2005
peer reviewed1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism.
Frahm, Thomas, Ehrchen, Jan, Lengeling, Andreas, Helming, Laura, Geffers, Robert, Probst-Kepper, Michael, Schiebe, Stefanie, L. Helming, Böse, Jens, Balling, Rudi   +9 more
core   +1 more source

1,25-dihydroxyvitamin-D3 but not the clinically applied marker 25-hydroxyvitamin-D3 predicts survival after stem cell transplantation. [PDF]

Bone Marrow Transplant, 2021
The serum level of 25-hydroxyvitamin-D3 is accepted as marker for a person’s vitamin D status but its role for the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is controversially discussed.
Peter K, Siska PJ, Roider T, Matos C, Bruns H, Renner K, Singer K, Weber D, Güllstorf M, Kröger N, Wolff D, Herr W, Ayuk F, Holler E, Stark K, Heid IM, Kreutz M.   +16 more
europepmc   +4 more sources

Successful Treatment for Hypercalcemia due to Cosecretion of Parathyroid Hormone-Related Protein and 1,25-Dihydroxyvitamin D3 in Non-Small-Cell Lung Cancer: A Case Report and Literature Review

Case Reports in Pulmonology, 2020
Hypercalcemia of malignancy frequently manifests as paraneoplastic syndrome in patients with solid tumors. A 71-year-old man was diagnosed with stage IIIB lung squamous cell carcinoma. Laboratory examination revealed high serum calcium concentration with
Takunori Ogawa, Jun Miyata, Koichi Fukunaga, Akihiko Kawana, Takashi Inoue   +4 more
doaj   +1 more source

Vitamin D Metabolites and Risk of Cardiovascular Disease in Chronic Kidney Disease: The CRIC Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The ratio of 24,25‐dihydroxyvitamin D3/25‐hydroxyvitamin D3 (vitamin D metabolite ratio [VDMR]) may reflect functional vitamin D activity. We examined associations of the VDMR, 25‐hydroxyvitamin D (25[OH]D), and 1,25‐dihydroxyvitamin D (1,25 ...
Simon Hsu, Leila R. Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I. Feldman, Charles Ginsberg, Andrew N. Hoofnagle, Tamara Isakova, Mary B. Leonard, Benjamin Lidgard, Cassianne Robinson‐Cohen, Myles Wolf, Dawei Xie, Bryan R. Kestenbaum, Ian H. de Boer   +15 more
doaj   +1 more source

Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

eLife, 2022
Pregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal health outcomes. Using physiological human placental perfusion and villous explants, we investigate the role of the placenta in regulating the relationships ...
Brogan Ashley, Claire Simner, Antigoni Manousopoulou, Carl Jenkinson, Felicity Hey, Jennifer M Frost, Faisal I Rezwan, Cory H White, Emma M Lofthouse, Emily Hyde, Laura DF Cooke, Sheila Barton, Pamela Mahon, Elizabeth M Curtis, Rebecca J Moon, Sarah R Crozier, Hazel M Inskip, Keith M Godfrey, John W Holloway, Cyrus Cooper, Kerry S Jones, Rohan M Lewis, Martin Hewison, Spiros DD Garbis, Miguel R Branco, Nicholas C Harvey, Jane K Cleal   +26 more
doaj   +1 more source

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey

Molecules, 2020
20(S)-Hydroxyvitamin D3 (20(OH)D3) is an endogenous metabolite produced by the action of CYP11A1 on the side chain of vitamin D3 (D3). 20(OH)D3 can be further hydroxylated by CYP11A1, CYP27A1, CYP24A1 and/or CYP27B1 to several hydroxyderivatives. CYP11A1
Tae-Kang Kim, Venkatram Atigadda, Pawel Brzeminski, Adrian Fabisiak, Edith K. Y. Tang, Robert C. Tuckey, Andrzej T. Slominski   +6 more
doaj   +1 more source

Comparison of cellular and transcriptional responses to 1,25-dihydroxyvitamin d3 and glucocorticoids in peripheral blood mononuclear cells. [PDF]

PLoS ONE, 2013
Glucocorticoids (GC) and 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3) are steroid hormones with anti-inflammatory properties with enhanced effects when combined.
Sonia S Kupfer, Joseph C Maranville, Shaneen S Baxter, Yong Huang, Anna Di Rienzo   +4 more
doaj   +1 more source

1α, 25-Dihydroxyvitamin D3 protects gastric mucosa epithelial cells against Helicobacter pylori-infected apoptosis through a vitamin D receptor-dependent c-Raf/MEK/ERK pathway

Pharmaceutical Biology, 2022
Context Due to the resistance of Helicobacter pylori to antibiotics, it is difficult to eradicate this pathogenic bacterium from the host. The role of 1α, 25-dihydroxyvitamin D3 (1,25-D3) in H.
Shuai Zhao, Daihong Wan, Yaoyao Zhong, Xiwei Xu   +3 more
doaj   +1 more source

The future of vitamin D analogs

Frontiers in Physiology, 2014
The active form of vitamin D3, 1,25-dihydroxyvitamin D3, is a major regulator of bone and calcium homeostasis. In addition, this hormone also inhibits the proliferation and stimulates the differentiation of normal as well as malignant cells ...
Carlien eLeyssens, Lieve eVerlinden, Annemieke eVerstuyf   +2 more
doaj   +1 more source

Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells [PDF]

, 1990
HL-60 leukemic cells were differentiated along the neutrophilic pathway with retinoic acid (RA) or along the monocytic pathway with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).
Seifert, Roland, Jungblut, P. R.
core   +1 more source