Results 91 to 100 of about 8,043 (225)
Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition [PDF]
, 2011 A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the ...
Engels, Joachim W. +2 more
core +2 more sources
Advanced Science, Volume 13, Issue 19, 2 April 2026.We have developed a Pd‐catalyzed oxidative cyclopropanation of 1,n‐enynes employing cyclic diacyl peroxides as bifunctional reagents that serve as both tether‐tunable oxidants and spatially controlled dicarboxylate anions. ABSTRACT Bicyclo[n.1.0]alkanes are highly valuable scaffolds in drug discovery and synthetic chemistry.
Ting Yuan, Lei Shi
wiley +1 more source
Pyrrolodiazines. 4. Structure and chemistry of 3,4-dihydropyrrolo[1,2-a]pyrazine [PDF]
, 1997 The structure of 3,4-dihydropyrrolo[1,2-a]pyrazine and its N-protonated form is studied by ab initio calculations. Examples of the reactivity of this poorly studied system are presented in which it is shown that the imino moiety does not react with ...
Andrés, José L. de +6 more
core +3 more sources
Stereoselective Intramolecular Azide 1,3-Dipolar Cycloaddition
HETEROCYCLES, 2003 Ethyl (E)-7-azido-6-[bis(tert-butoxycarbonyl)amino]-2-heptenoate undergoes a stereoselective intramolecular azide 1,3-dipolar cycloaddition leading to a stable triazoline. The configuration and the conformation of the triazoline obtained were determined by spectroscopic data and confirmed by molecular mechanics calculations.
Markidis, T., Mikros, E., Kokotos, G.
openaire +2 more sources
ChemistryEurope, Volume 4, Issue 4, April 2026.Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn +6 more
wiley +1 more source
A combined experimental and theoretical study of the polar [3+2] cycloaddition of electrophilically activated carbonyl ylides with aldehydes and imines [PDF]
, 2009 International audienceNumerous 2,5-diaryl-1,3-dioxolane-4,4-dicarbonitriles and 2,4-diphenyl-1,3-oxazolidine-5,5- dicarbonitriles have been synthesized by [3+2] cycloaddition reactions between carbonyl ylides generated from epoxides, and aldehydes or ...
Bentabed-Ababsa, Ghenia +7 more
core +3 more sources
Cyclodextrin‐Amino Acid Conjugates: Synthesis and Pharmaceutical Applications
ChemistryEurope, Volume 4, Issue 4, April 2026.Cyclodextrins (CDs) can be combined with amino acids via host‐guest complexation or by covalent conjugation through various synthetic routes. The chemical modifications introduce structural versatility, multifunctionality, and biocompatibility, which are essential characteristics for designing effective, next‐generation pharmaceutical formulations ...
Andrea Cesari +2 more
wiley +1 more source
Enantioselective 1,3-Dipolar Cycloadditions of α-Methylene Lactams to Construct Spirocycles. [PDF]
Org Lett, 2023 Nishiura Y +3 more
europepmc +1 more source
Microwave-assisted generation and reactivity of aza- and diazafulvenium methides: heterocycles via pericyclic reactions [PDF]
, 2008 Azafulvenium methides and diazafulvenium methides have been generated under microwave irradiation from 2,2-dioxo-1H,3H-pyrrolo[1,2-c]thiazoles and 2,2-dioxo-1H,3H-pyrazolo[1,5-c]thiazoles, respectively.
Melo, Teresa M. V. D. Pinho e +1 more
core +1 more source
Chemistry–Methods, Volume 6, Issue 4, April 2026.A modular late‐stage manifold exploits the embedded alkyne of alkynylbicyclo[1.1.0]butanes (ABCBs) to deliver triazole‐, isoxazole‐, free‐NH‐pyrrole, free‐NH‐pyrazole, or silacyclohexene‐decorated BCBs in a single operation. Strain‐release transformations of bicyclo[1.1.0]butanes are powerful methods for constructing four‐membered rings and bicyclo[n.1.
Yu‐Jie Li +3 more
wiley +1 more source