Results 201 to 210 of about 235,743 (243)

Aromatization of 1,4‐Dihydropyridines with Selenium Dioxide.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiao-hua Cai, Hai-jun Yang, Guo-lin Zhang   +2 more
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Dimeric 1,4-dihydropyridines as calcium channel antagonists

Journal of Medicinal Chemistry, 1988
A series of 1,n-alkanediylbis(1,4-dihydropyridines) (n = 2, 4, 6, 8, 10, 12) bridged at C3 of 2,6-dimethyl-3-carboxy-5-carbethoxy-4-(3-nitrophenyl)-1,4-dihydropyridin e were synthesized and evaluated in a radioligand binding assay, [3H]nitrendipine in intestinal smooth muscle, as Ca2+ channel ligands.
A F, Joslyn, E, Luchowski, D J, Triggle
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1,4-Dihydropyridines and the 1,4-Dihydropyridine Receptor

1993
The 1,4-dihydropyridine nifedipine is a first-generation drug of major significance in the treatment of cardiovascular disorders including hypertension, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which ...
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1,4-Dihydropyridine activators in the tiamdipine series

European Journal of Pharmacology, 1990
The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart.
GALLETTI, FERRUCCIO, Luchowski E, Triggle DJ   +2 more
openaire   +3 more sources

Photoprotection of 1,4-dihydropyridine derivatives by dyes

International Journal of Pharmaceutics, 2005
The possibility of increasing the photochemical stability of nisoldipine by using indigotine and azorubine as photoprotectors has been studied. The course of the photodegradation was monitored by means of UV-vis spectrophotometry and HPLC. Quantitative assessments of the nisoldipine photodegradation included evaluation of the quantum yields and kinetic
Jadwiga, Mielcarek, Włodzimierz, Augustyniak, Paweł, Grobelny, Grazyna, Nowacka   +3 more
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Catalytic Synthesis of Fused 1,4-Dihydropyridines and 1,4-Dihydropyridine Derivatives Using Preyssler Heteropolyacids Catalyst

Synthetic Communications, 2012
Abstract An efficient and convenient method for the synthesis of 1,4-dihydropyridines from β-dicarbonyl compounds, aldehydes, and ammonium acetate and the synthesis of fused 1,4-dihydropyridines from dimedone in the presence of Preyssler heteropolyacid catalyst are reported under reflux conditions with good to excellent yields. Preyssler heteropolyacid
Ali Gharib, Manouchehr Jahangir, Mina Roshani, J. (Hans) W. Scheeren   +3 more
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Cocrystals of diastereoisomers of 1,4-dihydropyridine derivatives

Acta Crystallographica Section C Crystal Structure Communications, 2006
A mixture of the RR/SS and RS/SR diastereoisomeric pairs of methyl 4-(2,4-dichlorophenyl)-2,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C 19 H 19 Cl 2 NO 3 , forms cocrystals in which there is one unique molecule in the asymmetric unit, but the molecule displays disorder in the region of the 7-position of the quinoline ring system as
Anthony, Linden, Miyase G, Gündüz, Rahime, Simşek, Cihat, Safak   +3 more
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1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine

Bioorganic & Medicinal Chemistry, 1996
A series of 1,4-dihydropyridines bearing a pharmacophoric fragment of lidoflazine was synthesized. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist activities. All compounds behave as inotropic and chronotropic agents, except for compounds 4b, 5a, and 5b, which exhibit a rather weak calcium antagonism in vascular smooth ...
Chiarini A., Rampa A., Budriesi R., Bisi A., Fabbri G., Valenti P.   +5 more
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¹⁵N NMR of 1,4‐dihydropyridine derivatives

Magnetic Resonance in Chemistry, 2013
In this article, we describe the characteristic 15N and 1HN NMR chemical shifts and 1J(15N–1H) coupling constants of various symmetrically and unsymmetrically substituted 1,4‐dihydropyridine derivatives. The NMR chemical shifts and coupling constants are discussed in terms of their relationship to structural features such as character and position of ...
Inguna, Goba, Edvards, Liepinsh
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The 1,4-Dihydropyridine Receptor

Journal of Cardiovascular Pharmacology, 1984
Evidence that nitrendipine (2,6-dimethyl-3-carbomethoxy-5-carbomethoxy-4-(3-nitrophenyl)1,4- dihydropyridine) and other 1,4-dihydropyridines interact at a specific site to antagonize Ca2+ channel function is reviewed. This evidence derives from electrophysiologic and pharmacologic studies and is confirmed by [3H]radioligand binding to excitable tissues.
D J, Triggle, R A, Janis
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