Results 151 to 160 of about 178,915 (221)

Emetine and Its Derivatives as Anticancer Agents Targeting the PI3K/AKT/mTOR Pathway: A Narrative Review of Mechanisms, Pharmacology, and Clinical Insights. [PDF]

J Cell Mol Med
Khatun MI, Selim S, Malik AH, Al Hasan MS, Khalipha ABR, Yana NT, Alshahrani MY, Hossain MA, Rakib IH, Chakrabarty A, Mia E.   +10 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Plant Phosphatidylinositol Signalling Network in Cotton Resistance to Verticillium Wilt. [PDF]

Plant Cell Environ
Liu Z, Sun X.
europepmc   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Novel role of the class II α-isoform of phosphatidylinositol 3-kinase in hepatocellular carcinoma: suppressing metastasis by targeting Wnt/β-catenin signaling via inhibiting phosphorylation of LRP6. [PDF]

Cancer Cell Int
Chen J, Ren LX, Ma Y, Cheng WH, Liu T.
europepmc   +1 more source

Linagliptin increases the expression of LRP2 independent of Nrf2 in streptozotocin‐induced diabetic mice

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Oxidative stress is thought to play a role in the onset and progression of diabetic nephropathy (DN). Nuclear factor erythroid‐related factor 2 (Nrf2) is a master regulator of antioxidant and detoxification pathways and provides cellular protection against oxidative stress.
Suratsawadee Promsuwan, Yumi Takiyama, Takao Takiyama, Yuri Takiyama, Hiroya Kitsunai, Hiroshi Nomoto   +5 more
wiley   +1 more source

Joint transcriptomic and metabolomic analyses of the mechanisms of <i>Juniperus tibetica</i> in response to <i>Arceuthobium oxycedri</i>. [PDF]

AoB Plants
Chen H, Bai L, Cao Y.
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Functional Characterization of Putative Novel MicroRNA-1133 in the Antioxidant Effects of Metformin in Hyperglycemia-Induced Endothelial Cells. [PDF]

Int J Mol Sci
Othman NS, Aminuddin A, Hamid AA, Abidin SZ, Syafruddin SE, Ahmad MF, Jaffar FHF, Othman Basri NA, Ugusman A.   +8 more
europepmc   +1 more source

Subversion of plant endomembrane trafficking by a Plasmodiophora brassicae effector PbALE that recruits membrane components at the host–pathogen interface to aid in colonization

New Phytologist, EarlyView.
Schematics of ΔSPPbALE‐induced disruption of plant endomembrane trafficking impairs both preinvasive and postinvasive immunity against filamentous fungi and facilitates intracellular colonization by Plasmodiophora brassicae. Summary Plasmodiophora brassicae, an intracellular biotrophic protist that causes clubroot in crucifers, extensively alters the ...
Musharaf Hossain, Jiangying Tu, Yangdou Wei, Peta C. Bonham‐Smith, Christopher D. Todd   +4 more
wiley   +1 more source