Results 171 to 180 of about 178,915 (221)

LAT condensation gates PLCγ1 activation via bimodal LAT phosphorylation. [PDF]

Proc Natl Acad Sci U S A
Ren H, Lee HR, Omar YAD, DeGrandchamp JB, Hung CL, Eisen TJ, Stamou D, Kuriyan J, Chakraborty AK, Groves JT.   +9 more
europepmc   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer. [PDF]

Cancer Rep (Hoboken)
Manav N, Kashyap A, Malhotra L, Rajegowda C, Prasad CP.   +4 more
europepmc   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B. [PDF]

Acta Crystallogr D Struct Biol
He Z, Chen S, Micheli F, Cianciulli A, Beato C, Ellman J, Ha Y.   +6 more
europepmc   +1 more source

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source

Phosphoinositides and inositol phosphates-functions and cellular dynamics. [PDF]

FEBS Lett
Rao F, Haucke V.
europepmc   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Phosphatidylinositol 4-kinase α suppresses glioblastoma progression by inactivating YAP and PI3K/Akt signaling. [PDF]

J Biol Chem
Liu J, Qian Y, Zhang J, Xing S, Huang Z, Jiang Y.   +5 more
europepmc   +1 more source