Results 191 to 200 of about 263,705 (311)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Unveiling the role of the PI3K/Akt signaling pathway in follicular development and non-malignant ovarian dysfunction: a comprehensive review. [PDF]

J Ovarian Res
He J, Gao H, Pan X.
europepmc   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, EarlyView.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

Rosa roxburghii Tratt. enhances fracture healing through multitarget regulation of osteogenesis and angiogenesis: Integrated network pharmacology and molecular docking analysis. [PDF]

Medicine (Baltimore)
Wu Z, Luo P, Liu H, Xu J, Ying Q, Zhang J, Xuan Z.   +6 more
europepmc   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Signalling mechanisms for Toll‐like receptor‐activated neutrophil exocytosis: key roles for interleukin‐1‐receptor‐associated kinase‐4 and phosphatidylinositol 3‐kinase but not Toll/IL‐1 receptor (TIR) domain‐containing adaptor inducing IFN‐β (TRIF)

, 2008
Agnieszka A. Brzezinska, Jennifer L. Johnson, Daniela B. Munafó, Beverly A. Ellis, Sergio Catz   +4 more
openalex   +2 more sources

Regulation of Cell Proliferation and Migration by Extracellular Phosphatidic Acid. [PDF]

Biomedicines
Gomez-Larrauri A, Benito-Vicente A, Uribe KB, Martin C, Gomez-Muñoz A.   +4 more
europepmc   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Arabidopsis Phosphatidylinositol Phosphate Kinase 1 Binds F-actin and Recruits Phosphatidylinositol 4-Kinase β1 to the Actin Cytoskeleton [PDF]

, 2007
Amanda Davis, Yang Ju Im, Joshua S. Dubin, Kenneth B. Tomer, Wendy F. Boss   +4 more
openalex   +1 more source

Insulin resistance induced by obesity: Mechanisms, metabolic implications and therapeutic approaches. [PDF]

Mol Biol Rep
Choo YN, Ravi RN, Subramaniyan V.
europepmc   +1 more source