Results 181 to 190 of about 178,915 (221)

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability. [PDF]

Cancers (Basel)
Ottaiano A, Picone C, Santorsola M, Berretta M, Cutolo C, Belli A, Izzo F, Di Carluccio N, Acampora A, Tarotto L, Stilo S, Correra M, Capuozzo M, Carratù AC, Caraglia M, Nasti G, Savarese G.   +16 more
europepmc   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

NRF2 Stabilization by Isoform-Specific Nuclear Phosphoinositides in Stress Response. [PDF]

Oral Sci Homeost Med
Tang Y, Chen Y, Carrillo ND, Cryns VL, Anderson RA, Sun J, Chen M.   +6 more
europepmc   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Pathophysiological mechanisms and therapeutic potential of E-selectin in pulmonary arterial hypertension. [PDF]

Front Immunol
Lama E, Wang Y, Wu J, Ma Q, Chen H, Wang Y, Yang Y, Liu C, Ni X, Zhou Z.   +9 more
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

PDK1-mediated PI3K/Akt signaling regulates metabolic and developmental programs in a cosmopolitan pest. [PDF]

Pest Manag Sci
Yan M, Xie L, Li B, Hu J, Chen B, You M, Liu Y, Gurr GM, Li J, You S.   +9 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

<i>Ligusticum sinense</i> Oliv. cv. Chaxiong Extract Alleviates Nitroglycerin-Induced Migraine-like Responses in Rats: Associations with Glycerophospholipid Metabolism and PI3K/AKT Signaling. [PDF]

Int J Mol Sci
Zhu Y, Dong Y, Jiang S, Qin Q, He Y, Wu D, Zhang S, Wei J.   +7 more
europepmc   +1 more source