Results 181 to 190 of about 173,400 (218)

PI3K/Akt Signaling as a Potential Therapeutic Target for Reducing Inflammation and Corneal Stromal Injury in Microsporidial Stromal Keratitis. [PDF]

Invest Ophthalmol Vis Sci
Wei Y, Xu X, Peng Y, Pang J, Chen Q, Peng B, Shen S, Liang Q.   +7 more
europepmc   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks. [PDF]

J Biol Chem
Llorente A, Arora GK, Loughran RM, Murad R, Maurya S, Crabtree S, Portillo B, Chapagain P, Huluka H, Eron S, Goodman K, Ye G, Blind RD, Emerling BM.   +13 more
europepmc   +1 more source

3,3′,4,5′‐Tetramethoxy‐trans‐stilbene Alleviates Metabolic Dysfunction‐Associated Steatotic Liver Disease

eFood, Volume 7, Issue 4, August 2026.
3,3′,4,5′‐Tetramethoxy‐trans‐stilbene alleviates hepatic insulin resistance and metabolic dysfunction‐associated steatotic liver disease, through the activation of IRS/PI3K/Akt/GSK3β/GS and Nrf2/HO‐1 pathways, in diet‐induced obese mice. The figure was created with MedPeer (medpeer.cn).
Qiaowen Deng, Yuehan Wang, Feiyang Zheng, Manqin Fu, Chumin Zhong, Dharmani Devi Murugan, Wai San Cheang   +6 more
wiley   +1 more source

Alzheimer's Protection by PLCγ2 Compacts Plaques, Redistributes Microglia, and Protects Synapses in AppNL‐G‐F Mice

Glia, Volume 74, Issue 8, August 2026.
The Alzheimer's disease protective PLCG2 P522R variant protects against amyloid‐induced synapse loss independently of amyloid load, promotes increased plaque compaction, and is associated with enhanced microglial engagement with diffuse amyloid. ABSTRACT The Alzheimer's disease protective P522R PLCG2 coding variant (rs72824905) is downstream of TREM2 ...
Ryan J. Bevan, Emily Maguire, Eilish Mackinnon, Elisa Salis, Thomas Phillips, Elena Simonazzi, Marieta Vassileva, Nicholas D. Allen, Julie Williams, Philip R. Taylor   +9 more
wiley   +1 more source

Deciphering the Functional Mechanisms of eIF3f in Tumors and Exploring Targeted Therapies

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a critical component of the eIF3 complex and plays a pivotal role in diverse biological processes, including cell proliferation, apoptosis, adhesion, and transcriptional regulation.
Yujinpeng Hao, Jun Shao, Naqi Lian, Mianli Bian   +3 more
wiley   +1 more source

Treatment with Kinase Inhibitors Plus Myo-Inositol as Re-Differentiating Agents in Iodine-Refractory Thyroid Cancers. [PDF]

Life (Basel)
Giani C, Russo M, Lapi P, Profilo MA, Forleo R, Mazzi B, Ghirri A, Caresia L, Campennì A, Durante C, Corsello A, Morganti R, Unfer V, Paragliola RM, Barbaro D.   +14 more
europepmc   +1 more source

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older‐Age Bipolar Disorder ISBD Task Forces

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders, Sigfried N. T. M. Schouws, Andrew T. Olagunju, Vicent Balanzá‐Martínez, Nicole C. M. Korten, Ralph W. Kupka, Katherine E. Burdick, Andre F. Carvalho, Ariel G. Gildengers, Lars V. Kessing, Roger S. McIntyre, Paula V. Nunes, Ayal Schaffer, Ivan J. Torres, Shang‐Ying Tsai, Tamsyn E. Van Rheenen, Eduard Vieta, Lakshmi N. Yatham, Allan H. Young, Lisa T. Eyler, Kamilla W. Miskowiak, Annemiek Dols   +21 more
wiley   +1 more source

Mitochondrial Dysfunction in <i>Ehrlichia canis</i> Infection. [PDF]

Transbound Emerg Dis
Tong X, Jiang J, Yang L, Liu Y, Chen L, Fu X, Yu G, Chen N, Tian S, Huang S, Huang S, Buzdar JA, Chen X, Liu Z.   +13 more
europepmc   +1 more source

Effect of lumbrokinase on a rat model of hyperlipidemia-induced erectile dysfunction. [PDF]

Transl Androl Urol
Li X, Sun Y, Zhang X, Zhang Z, Han Z, Chen Y.   +5 more
europepmc   +1 more source