Results 271 to 280 of about 263,705 (311)

Electroacupuncture improves diabetes-associated cognitive impairment in rats: potential involvement of hippocampal insulin receptor substrates 1/phosphatidylinositol 3-kinase/protein kinase B signaling pathway activation. [PDF]

Neuroreport
Zhang L, Song H, Ye M, Kan W, Hu Y, Xie H, Yuan A.   +6 more
europepmc   +1 more source

Clinical implications of PD‐L1 expression in oncogene‐driven NSCLC: Differential responses to targeted agents and immune checkpoint inhibitors

International Journal of Cancer, Volume 159, Issue 1, Page 269-279, 1 July 2026.
What's New? PD‐L1 is a reliable biomarker for predicting immunotherapy efficacy in patients with non‐small‐cell lung cancer lacking oncogenic driver mutations. However, its significance in patients with driver mutations remains unclear. In this study of 273 patients with stage IV non–‐small‐cell lung cancer harboring diverse driver alterations and PD ...
Xiaoxiao Fan, Chenxi Wei, Minjun Rong, Shengnan Wang, Jiaying Wang, Xiaohan Wang, Xiao Han, Xue Meng   +7 more
wiley   +1 more source

Phosphoinositide 3-kinase δ activity in patients with systemic lupus erythematosus. [PDF]

Front Immunol
Mirfazeli ES, Kharkar S, Tsang-A-Sjoe MWP, Papapietro O, Niewczas I, Parra Sanchez AR, Chandra A, Okkenhaug K, Bultink IEM, Mebius RE, Clark J, Voskuyl AE, Nejentsev S.   +12 more
europepmc   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Reigniting the Flame for Redifferentiation Strategies in Differentiated Thyroid Cancers: Journey of Tyrosine Kinase Inhibitors to Renewed Radioactive-Iodine Avidity. [PDF]

Endocrinol Metab (Seoul)
Oh JM, Zhu L, Ahn BC.
europepmc   +1 more source

Equol Alleviates Postmenopausal Metabolic Dysfunction‐Associated Steatotic Liver Disease via the GPR30/PI3K Pathway

eFood, Volume 7, Issue 3, June 2026.
This study demonstrates that equol exerts a protective effect on metabolic dysfunction‐associated steatotic liver disease in both in vivo and in vitro by activating the GPR30/PI3K/Nrf2 signaling pathway. Equol's interaction with GPR30 and its ability to activate the PI3K/Nrf2 pathway provide a promising therapeutic strategy for treating metabolic ...
Hanqiang Cui, Bin Wang, Bo Zou, Guiming Zhang, Zhe Xu, Shuo Li, Jing Xu, Xiangmin Ni, Jian Wang   +8 more
wiley   +1 more source

Endometriosis-derived exosomal MicroRNA-125b-5p downregulates phosphatidylinositol 3-Kinase/Protein Kinase B signaling pathways via vascular endothelial growth factor to decelerate endometriosis progression. [PDF]

Mol Biol Rep
Zhang L, Zhu L, Luo H, Chen X, Yu G, Li Q, Chen M, Jin P, Shi Q.   +8 more
europepmc   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

<i>PTEN</i> Gene and Autism: Genetic Underpinnings and Neurodevelopmental Impacts. [PDF]

Genes (Basel)
Genovese AC, Butler MG.
europepmc   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source