Results 41 to 50 of about 173,548 (124)

Molecular Basis of Meiotic Maturation and Apoptosis of Oocytes, Sperm-Oocyte Interactions and Early Cleavage of Embryos in Mice, Role of Phosphatidylinositol 3-Kinase, Mos, Fas-Fas Ligand, Integrinα6 and MAP Kinase [PDF]

Cell Journal, 2005
The interaction between molecular biology and embryology made an extensive progress in the research on gametogenesis, fertilization and early embryogenesis in mice.
Yumi Hoshino, Ken-ichi Yamanaka, Ikuo Tomioka, Noritaka Fukunaga, Mehdi Abbasi, Eimei Sato   +5 more
doaj  

Manipulation of macrophage signaling by Leishmania virulence factors

Virulence
Leishmania, a macrophage-residing parasite, expresses virulence factors that intercept macrophage signaling and inflicts leishmaniasis. Recently described virulence factors- eEF-1α (eukaryotic elongation factor), LmjF_36_3850 (Leishmania major F_36_3850),
Dhiraj Gurjar, Neelam Bodhale, Divanshu Shukla, Debadatta Nayak, Nibedita Lenka, Bhaskar Saha   +5 more
doaj   +1 more source

Immune Checkpoints Mediate Tumor Immune Regulation 
through Metabolic Pathways

Chinese Journal of Lung Cancer
Immune checkpoints include a series of receptor-ligand pairs that play a key role in the proliferation, activation, and immune regulatory responses of immune cells.
Weiguang DU, Xiyang TANG, Yulong ZHOU, Mengchao LI, Ze JIN, Jiaqi DOU, Jinbo ZHAO   +6 more
doaj   +1 more source

Reversible arginine methylation of PI3KC2α controls mitotic spindle dynamics

Cell Communication and Signaling
Microtubules, composed of αβ-tubulin dimers, undergo dynamic polymerization and are fundamental to cell structure and function. In the current study, we discovered that phosphatidylinositol 3-kinase class 2α (PI3KC2α) acts as a novel regulatory factor in
Yena Cho, Jee Won Hwang, Mark T. Bedford, Dong Hee Na, Dae-Geun Song, Su-Nam Kim, Yong Kee Kim   +6 more
doaj   +1 more source

Curcumin ameliorates hepatic insulin resistance by activating PINK1/Parkin-mediated mitophagy

Scientific Reports
Insulin resistance (IR) is the key pathogenic factor of type 2 diabetes (T2DM) and its associated metabolic diseases. Mitochondrial dysfunction and inadequate mitophagy are central to this pathology. Curcumin, the main bioactive compound of Curcuma longa,
Zhanhong Guo, Huan Zhang, Yinghong Kong
doaj   +1 more source

Macrophage glycine transporter supports IL-1β production by modulating the AKT1/mTOR/NLRP3 pathway

Cell Reports
Summary: Increasing investigations indicate that neurotransmitters shape immune cell function; however, current results about glycine (Gly) in inflammatory macrophage responses are conflicting. Here, we found that Gly transporters support interleukin-1β (
Yan Guo, Xiaoyan Wu, Xinmei Zhang, Qilin Hu, Zhending Gan, Shijie Liu, Xuehua Mei, Xiu Zeng, Wenkai Ren   +8 more
doaj   +1 more source

Signal Transduction of Transient Receptor Potential TRPM8 Channels: Role of PIP5K, Gq-Proteins, and c-Jun

Molecules
Transient receptor potential melastatin-8 (TRPM8) is a cation channel that is activated by cold and “cooling agents” such as menthol and icilin, which induce a cold sensation.
Gerald Thiel, Oliver G. Rössler
doaj   +1 more source

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science
Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related mortality worldwide. Ferroptosis, an iron‐dependent form of programmed cell death driven by lipid peroxidation, has emerged as a promising strategy for cancer treatment.
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
doaj   +1 more source

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells

Drug Design, Development and Therapy, 2015
Yong-Hui Ding,1,2 Zhi-Wei Zhou,2,3 Chun-Fang Ha,1 Xue-Yu Zhang,1 Shu-Ting Pan,4 Zhi-Xu He,3 Jeffrey L Edelman,2 Dong Wang,5 Yin-Xue Yang,6 Xueji Zhang,7 Wei Duan,8 Tianxin Yang,9 Jia-Xuan Qiu,4 Shu-Feng Zhou2,3 1Department of Gynecology, General ...
Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang ZX, Zhang XJ, Duan W, Yang TX, Qiu JX, Zhou SF   +13 more
doaj  

Decoding protein-phospholipid interaction networks in cancer: the role of acyl-chain remodeling. [PDF]

RSC Chem Biol
Blume B, Potter G, Schultz C, Emili A.
europepmc   +1 more source