Results 31 to 40 of about 173,548 (124)

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.

PLoS Pathogens, 2013
The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an essential host factor of hepatitis C virus (HCV) replication. PI4KIIIα catalyzes the synthesis of phosphatidylinositol 4-phosphate (PI4P) accumulating in HCV replicating cells due ...
Simon Reiss, Christian Harak, Inés Romero-Brey, Danijela Radujkovic, Rahel Klein, Alessia Ruggieri, Ilka Rebhan, Ralf Bartenschlager, Volker Lohmann   +8 more
doaj   +1 more source

Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver

Redox Biology, 2018
Protein kinase B (PKB/Akt) plays important roles in the regulation of lipid homeostasis, and impairment of Akt activity has been demonstrated to be involved in the development of non-alcoholic fatty liver disease (NAFLD).
Tao Zeng, Cui-Li Zhang, Ning Zhao, Min-Jie Guan, Mo Xiao, Rui Yang, Xiu-Lan Zhao, Li-Hua Yu, Zhen-Ping Zhu, Ke-Qin Xie   +9 more
doaj   +1 more source

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

Animal Models and Experimental Medicine
Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer (CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing
Mohammad Yasin Zamanian, Niloofar Taheri, Montather F. Ramadan, Yasser Fakri Mustafa, Safa Alkhayyat, Klunko Nataliya Sergeevna, Hashem O. Alsaab, Ahmed Hjazi, Farnoosh Molavi Vasei, Siamak Daneshvar   +9 more
doaj   +1 more source

Novel therapeutic roles of MC‐4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of rapamycin complex 1 pathways

Cancer Medicine, 2018
Current clinical trials of new anticancer therapies against metastatic renal cell carcinoma (RCC), including molecular‐targeted therapies, have not shown promise.
Ji Yeon Son, Sungpil Yoon, In Hwan Tae, Yu Jin Park, Umasankar De, Yukyoung Jeon, Young Ju Park, Im Joo Rhyu, Byung Mu Lee, Kyu‐Huck Chung, Joung Eun Lim, Se Jeong Lee, Hye Won Lee, Jong Hwan Kwak, Hyung Sik Kim, Han Yong Choi   +15 more
doaj   +1 more source

Hepatocyte growth factor promotes migration of human myeloma cells

Haematologica, 2008
Multiple myeloma is characterized by the accumulation and dissemination of malignant plasma cells in the bone marrow. Cell migration is thought to be important for these events.
Randi Utne Holt, Unn-Merete Fagerli, Vadim Baykov, Torstein Baade Rø, Håkon Hov, Anders Waage, Anders Sundan, Magne Børset   +7 more
doaj   +1 more source

Molecular Modeling, Synthesis and Biological Evaluation of N-Phenyl-4-Hydroxy-6-Methyl-2-Quinolone-3-CarboxAmides as Anticancer Agents

Molecules, 2020
The emergence of phosphatidylinositol 3-kinase (PI3Kα) in cancer development has accentuated its significance as a potential target for anticancer drug design.
Dima A. Sabbah, Shaima’ E. Hasan, Reema Abu Khalaf, Sanaa K. Bardaweel, Rima Hajjo, Khalid M. Alqaisi, Kamal A. Sweidan, Aya M. Al-Zuheiri   +7 more
doaj   +1 more source

Analysis of the mechanism of skeletal muscle atrophy from the pathway of decreased protein synthesis

Frontiers in Physiology
Skeletal muscle atrophy is associated with denervation, cancer, diabetes, aging, immobilization, and inflammation, which can significantly impair mobility.
Peng Chen, Fangfang Jia, Meng Wang, Shengbo Yang   +3 more
doaj   +1 more source

ACBD3 Interaction with TBC1 Domain 22 Protein Is Differentially Affected by Enteroviral and Kobuviral 3A Protein Binding

mBio, 2013
Despite wide sequence divergence, multiple picornaviruses use the Golgi adaptor acyl coenzyme A (acyl-CoA) binding domain protein 3 (ACBD3/GCP60) to recruit phosphatidylinositol 4-kinase class III beta (PI4KIIIβ/PI4KB), a factor required for viral ...
Alexander L. Greninger, Giselle M. Knudsen, Miguel Betegon, Alma L. Burlingame, Joseph L. DeRisi   +4 more
doaj   +1 more source

Antidiabetic Activity of Zingiber officinale Roscoe Rhizome Extract: an In Vitro Study

Hayati Journal of Biosciences, 2018
The potential roles of Zingiber officinale Roscoe (ginger) for treating and preventing diabetes have been investigated in both humans and experimental animals. However, the mode of its action has not yet been elucidated.
Kusumarn Noipha, Putrada Ninla-Aesong
doaj   +1 more source

Cyclocarya paliurus extract activates insulin signaling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion.

PLoS ONE, 2017
Diabetes is caused by the lack of release or action of insulin. Some foods and supplements can compensate for this deficiency; thus, they can aid in the prevention or treatment of diabetes.
Hisae Yoshitomi, Rika Tsuru, Linyi Li, Jingxin Zhou, Maya Kudo, Tonghua Liu, Ming Gao   +6 more
doaj   +1 more source