Results 11 to 20 of about 173,400 (218)

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Journal of Ginseng Research, 2021
Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects.
Yan Wan, Jing Wang, Jin-feng Xu, Fei Tang, Lu Chen, Yu-zhu Tan, Chao-long Rao, Hui Ao, Cheng Peng   +8 more
doaj   +1 more source

Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils

Blood Advances, 2018
: Rolling neutrophils receive signals while engaging P- and E-selectin and chemokines on inflamed endothelium. Selectin signaling activates β2 integrins to slow rolling velocities. Chemokine signaling activates β2 integrins to cause arrest.
Tadayuki Yago, Nan Zhang, Liang Zhao, Charles S. Abrams, Rodger P. McEver   +4 more
doaj   +1 more source

Identification of novel regulators of STAT3 activity.

PLoS ONE, 2020
STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes.
Elina Parri, Heikki Kuusanmäki, Arjan J van Adrichem, Meri Kaustio, Krister Wennerberg   +4 more
doaj   +1 more source

Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

Scientific Reports, 2017
Exendin-4 (EX-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake and to increase proopiomelanocortin (POMC) gene expression in the hypothalamus. In this study, we examined the potential neural mechanisms by which
Yan Yang, Pique P. Choi, Wanli W. Smith, Weijie Xu, Delin Ma, Zachary A. Cordner, Nu-Chu Liang, Timothy H. Moran   +7 more
doaj   +1 more source

Activation of COUP-TFI by a Novel Diindolylmethane Derivative

Cells, 2019
Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is an orphan receptor and member of the nuclear receptor superfamily. Among a series of methylene substituted diindolylmethanes (C-DIMs) containing substituted phenyl and ...
Kyungsil Yoon, Chien-Cheng Chen, Asuka A. Orr, Patricia N. Barreto, Phanourios Tamamis, Stephen Safe   +5 more
doaj   +1 more source

DPHB, a diarylheptane from Alpinia officinarum Hance, ameliorates insulin resistance: A network pharmacology and in vitro study

Frontiers in Pharmacology, 2022
(4E)-7-(4-Hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB) derived from A. officinarum Hance has been reported to exert anti-inflammatory and anti-insulin resistance (IR) effects. We explored the molecular mechanism of DPHB ameliorating IR through
Xiangyi Li, Huan Wen, Yuxin Zhang, Aixia Liu, Xuguang Zhang, Minghai Fu, Yipeng Pan, Jian Xu, Junqing Zhang   +8 more
doaj   +1 more source

Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer

Open Biology
Exomer is a protein complex that facilitates trafficking between the Golgi and the plasma membrane (PM). Schizosaccharomyces pombe exomer is composed of Cfr1 and Bch1, and we have found that full activation of the cell integrity pathway (CIP) in response
Esteban Moscoso-Romero, Sandra Moro, Alicia Duque, Francisco Yanguas, M.-Henar Valdivieso   +4 more
doaj   +1 more source

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1. [PDF]

PLoS ONE, 2014
Combination antiretroviral therapy (cART) can effectively suppress HIV-1 replication, but the latent viral reservoir in resting memory CD4(+) T cells is impervious to cART and represents a major barrier to curing HIV-1 infection.
Geneviève Doyon, Michele D Sobolewski, Kelly Huber, Deborah McMahon, John W Mellors, Nicolas Sluis-Cremer   +5 more
doaj   +1 more source

Computational and Pharmacological Evaluation of Ferrocene-Based Acyl Ureas and Homoleptic Cadmium Carboxylate Derivatives for Anti-diabetic Potential

Frontiers in Pharmacology, 2018
We investigated possible anti-diabetic effect of ferrocene-based acyl ureas: 4-ferrocenyl aniline (PFA), 1-(4-chlorobenzoyl)-3-(4-ferrocenylphenyl) urea (DPC1), 1-(3-chlorobenzoyl)-3-(4-ferrocenylphenyl) urea (DMC1), 1-(2-chlorobenzoyl)-3-(4 ...
Shahar Bano, Arif-ullah Khan, Faiza Asghar, Faiza Asghar, Muhammad Usman, Amin Badshah, Saqib Ali   +6 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source