Results 11 to 20 of about 178,915 (221)

Threonine 348 regulates the subcellular localization of PTEN. [PDF]

FEBS Open Bio
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Kato T, Tanaka S, Ohashi M.
europepmc   +2 more sources

Ciliary Membrane Lipid Homeostasis in Health and Disease. [PDF]

Adv Sci (Weinh)
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Huang Z, Liu YY, Sun H, Liu P.
europepmc   +2 more sources

Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils

Blood Advances, 2018
: Rolling neutrophils receive signals while engaging P- and E-selectin and chemokines on inflamed endothelium. Selectin signaling activates β2 integrins to slow rolling velocities. Chemokine signaling activates β2 integrins to cause arrest.
Tadayuki Yago, Nan Zhang, Liang Zhao, Charles S. Abrams, Rodger P. McEver   +4 more
doaj   +1 more source

Identification of novel regulators of STAT3 activity.

PLoS ONE, 2020
STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes.
Elina Parri, Heikki Kuusanmäki, Arjan J van Adrichem, Meri Kaustio, Krister Wennerberg   +4 more
doaj   +1 more source

Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

Scientific Reports, 2017
Exendin-4 (EX-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake and to increase proopiomelanocortin (POMC) gene expression in the hypothalamus. In this study, we examined the potential neural mechanisms by which
Yan Yang, Pique P. Choi, Wanli W. Smith, Weijie Xu, Delin Ma, Zachary A. Cordner, Nu-Chu Liang, Timothy H. Moran   +7 more
doaj   +1 more source

Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Journal of Ginseng Research, 2021
Chemotherapy-induced side effects affect the quality of life and efficacy of treatment of cancer patients. Current approaches for treating the side effects of chemotherapy are poorly effective and may cause numerous harmful side effects.
Yan Wan, Jing Wang, Jin-feng Xu, Fei Tang, Lu Chen, Yu-zhu Tan, Chao-long Rao, Hui Ao, Cheng Peng   +8 more
doaj   +1 more source

Activation of COUP-TFI by a Novel Diindolylmethane Derivative

Cells, 2019
Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is an orphan receptor and member of the nuclear receptor superfamily. Among a series of methylene substituted diindolylmethanes (C-DIMs) containing substituted phenyl and ...
Kyungsil Yoon, Chien-Cheng Chen, Asuka A. Orr, Patricia N. Barreto, Phanourios Tamamis, Stephen Safe   +5 more
doaj   +1 more source

PLCd4 signaling-mediated PI4P synthesis drives macrophage NLRP3 inflammasome activation to promote heat stroke-induced tissue injury

Cell Reports
Summary: Heat stroke causes life-threatening systemic inflammation and multiorgan injury, but the intracellular mechanisms that sustain inflammatory amplification after heat exposure remain unclear.
Riqing Wei, Wenqian Zheng, Chenxin Liu, Dinghao Dang, Xinyu Deng, Xiaoting Hu, Hui Liang, Xi Luo, Jiayi Tang, Wei Zhu, Shuogui Xu, Ru Li, Qiang Ma   +12 more
doaj   +1 more source

Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer

Open Biology
Exomer is a protein complex that facilitates trafficking between the Golgi and the plasma membrane (PM). Schizosaccharomyces pombe exomer is composed of Cfr1 and Bch1, and we have found that full activation of the cell integrity pathway (CIP) in response
Esteban Moscoso-Romero, Sandra Moro, Alicia Duque, Francisco Yanguas, M.-Henar Valdivieso   +4 more
doaj   +1 more source

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1. [PDF]

PLoS ONE, 2014
Combination antiretroviral therapy (cART) can effectively suppress HIV-1 replication, but the latent viral reservoir in resting memory CD4(+) T cells is impervious to cART and represents a major barrier to curing HIV-1 infection.
Geneviève Doyon, Michele D Sobolewski, Kelly Huber, Deborah McMahon, John W Mellors, Nicolas Sluis-Cremer   +5 more
doaj   +1 more source