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Biosynthesis of 10-Hydroxy-2-Decenoic Acid in Escherichia coli
Metabolic Engineering10-hydroxy-2-decenoic acid (10-HDA), a unique unsaturated fatty acid present in royal jelly, has attracted considerable interest due to its potential medical applications. However, its low concentration in royal jelly and complex conformational structure present challenges for large-scale production. In this study, we designed and constructed a de novo
Junfeng Shen, Xiaozhou Luo
exaly +3 more sources
Phytomedicine
10‑hydroxy-2-decenoic acid (10-HDA), the major fatty acid in royal jelly, exhibits antibacterial, anti-inflammatory, and antioxidant properties, suggesting its potential therapeutic benefits for traumatic brain injury (TBI). TBI induces significant neurological deficits through cell death, including pyroptosis. Although the role of copper in cell death
Xinqi Huang, Yumei An, Haiyan Shan
exaly +3 more sources
10‑hydroxy-2-decenoic acid (10-HDA), the major fatty acid in royal jelly, exhibits antibacterial, anti-inflammatory, and antioxidant properties, suggesting its potential therapeutic benefits for traumatic brain injury (TBI). TBI induces significant neurological deficits through cell death, including pyroptosis. Although the role of copper in cell death
Xinqi Huang, Yumei An, Haiyan Shan
exaly +3 more sources
Determination of (E)-10-hydroxy-2-decenoic acid content in pure royal jelly: A comparison between a new CZE method and HPLC [PDF]
Journal of Separation Science, 2007 A new CZE method was developed and compared with HPLC for the determination of (E)-10-hydroxy-2-decenoic acid (10-HDA) in commercial pure royal jelly (RJ) samples of different geographical origin.
Federico Ferioli +2 more
exaly +2 more sources
Chromatographia, 1995
The application of capillary electrophoresis (CE) to the separation and determination of the active ingredient, 10-hydroxy-2-decenoic acid, in royal jelly with direct on-column UV detection at 214 nm is described. Using a cathodic injection and anodic detection scheme, 10-hydroxy-2-decenoic acid (10-HDA) was separated and detected in less than 10 min ...
null Li Jia +3 more
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The application of capillary electrophoresis (CE) to the separation and determination of the active ingredient, 10-hydroxy-2-decenoic acid, in royal jelly with direct on-column UV detection at 214 nm is described. Using a cathodic injection and anodic detection scheme, 10-hydroxy-2-decenoic acid (10-HDA) was separated and detected in less than 10 min ...
null Li Jia +3 more
openaire +1 more source
Absence of 10-Hydroxy-2-Decenoic Acid (10-HDA) in Bee-Collected Pollen
1986Much attention has been paid to the survival of bee-collected pollen in pellets as well as those sticking to body hairs. This interest stems from plant breeders concern to prevent contamination when using bees for pollination purposes in isolation cages on the one hand and, on the other hand, one would like to use bee-collected pollen to improve seed ...
Verhoef, H.C.M., Hoekstra, F.A.
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International Immunopharmacology, 2015
To reveal the mechanism of 10H2DA inhibiting the proliferation of fibroblast-like synoviocytes (FLSs) of RA patients. Cell proliferation, HDAC activity and histone acetylation level of FLS cells treated with 10H2DA were detected by MTT assay, Colorimetric HDAC Activity Assay and Western-blot.
Jianguang, Wang +11 more
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To reveal the mechanism of 10H2DA inhibiting the proliferation of fibroblast-like synoviocytes (FLSs) of RA patients. Cell proliferation, HDAC activity and histone acetylation level of FLS cells treated with 10H2DA were detected by MTT assay, Colorimetric HDAC Activity Assay and Western-blot.
Jianguang, Wang +11 more
openaire +2 more sources
ChemSusChem, 2021
Abstract10‐Hydroxy‐2‐decenoic acid (10‐HDA) is a terminal hydroxylated medium‐chain α,β‐unsaturated carboxylic acid that performs various unique physiological activities and has a wide market value. Therefore, development of an environmentally friendly, safe, and high‐efficiency route to synthesize 10‐HDA is required.
Yan Li +10 more
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Abstract10‐Hydroxy‐2‐decenoic acid (10‐HDA) is a terminal hydroxylated medium‐chain α,β‐unsaturated carboxylic acid that performs various unique physiological activities and has a wide market value. Therefore, development of an environmentally friendly, safe, and high‐efficiency route to synthesize 10‐HDA is required.
Yan Li +10 more
openaire +2 more sources
10-Hydroxy-2-decenoic Acid as an Antimicrobial Agent in Draft Keg-Conditioned Wheat Beer
Journal of the American Society of Brewing Chemists, 2010In nature, 10-hydroxy-2-decenoic acid (10-HDA), an important unsaturated fatty acid, is only available in royal jelly.
Shanshan Li +3 more
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Purification and identification of 10-hydroxy-2-decenoic acid from pure royal jelly
2004The chemical nature of the royal jelly (RJ) has received considerable attention over the past 20 years. Genc and Aslan reported the determination of Trans-10-hydroxy-2-decenoic acid (10-HDA) content in pure Royal Jelly and royal jelly products by column liquid chromatography. Antinelli et al.
Honary, S +3 more
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Amino Acids, 2017
10-Hydroxy-2-decenoic acid (10-HDA) is the major compound produced from the mandibular glands (MGs) of honey bee workers. However, little information is available on the molecular mechanisms of 10-HDA biosynthesis. In our study, based on investigating the 10-HDA secretion pattern and the morphological characteristics of MGs from honey bee workers of ...
Xiao-Hui, Yang +2 more
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10-Hydroxy-2-decenoic acid (10-HDA) is the major compound produced from the mandibular glands (MGs) of honey bee workers. However, little information is available on the molecular mechanisms of 10-HDA biosynthesis. In our study, based on investigating the 10-HDA secretion pattern and the morphological characteristics of MGs from honey bee workers of ...
Xiao-Hui, Yang +2 more
openaire +2 more sources