Results 1 to 10 of about 6,620 (109)

Antitumor Effects and the Potential Mechanism of 10-HDA against SU-DHL-2 Cells [PDF]

Pharmaceuticals
10-hydroxy-2-decenoic acid (10-HDA), which is a unique bioactive fatty acid of royal jelly synthesized by nurse bees for larvae and adult queen bees, is recognized for its dual utility in medicinal and nutritional applications.
Wenchao Yang, Yuanyuan Tian
exaly   +4 more sources

Enhancing 10-HDA production of Escherichia coli by heterologous expression of MexHID transporter proteins [PDF]

Frontiers in Bioengineering and Biotechnology
10-Hydroxy-2-decenoic acid (10-HDA) is a medium-chain α,β-unsaturated carboxylic acid that exists in royal jelly with terminal hydroxylation. It has a broad market value because of its antibacterial, anti-inflammatory, anti-tumor, anti-radiation, and ...
Ziting Xu, Chaofan Du, Sheng Gao, Xinrui Yan, Pan Deng, Yuehan Liu, Junqing Wang, Junqing Wang, Ruiming Wang, Ruiming Wang, Nan Li, Nan Li   +11 more
doaj   +2 more sources

Recent Advances in 10-Hydroxy-2-Decenoic Acid (10-HDA): Biosynthesis, Biological Functions, and Regulatory Mechanisms in Honeybees [PDF]

Foods
Royal jelly (RJ) is a highly valued bee-derived functional food and natural health product, in which 10-hydroxy-2-decenoic acid (10-HDA) represents the most characteristic lipid component. As a unique fatty acid found exclusively in RJ, 10-HDA serves not
Peiyuan Zou, Yunxiao Hu, Bin Yuan, Pengbo Liang, Shanshan Li, Fuliang Hu   +5 more
doaj   +2 more sources

10-HDA attenuates inflammatory responses in LPS-activated RAW264.7 cells in vitro via the NUR77/NF-κB pathways and improving mitochondrial functions [PDF]

Frontiers in Pharmacology
BackgroundInflammation is implicated in the pathogenesis of various diseases, including cancer, diabetes, and diseases caused by bacterial infections. Macrophages, as key regulators of inflammatory responses, can polarize into distinct phenotypes such as
Kangwei Zhang, Kangwei Zhang, Zhen Zhou, Zhen Zhou, Haoxiang Ou, Haoxiang Ou, Xiaoli Fu, Xiaoli Fu, Jiaqi Xiao, Jiaqi Xiao, Xinyi Pan, Xinyi Pan, Long Wang, Bo Xu, Yanting Su, Mingjie Wei, Zhenwang Zhang, Liqiong Huang, Yongfen Bao, Yongfen Bao, Shigang Shan, Shigang Shan   +21 more
doaj   +2 more sources

Dissecting the Molecular Mechanism of 10-HDA Biosynthesis: Role of Acyl-CoA Delta(11) Desaturase and Transcriptional Regulators in Honeybee Mandibular Glands [PDF]

Insects
10-Hydroxy-2-decenoic acid (10-HDA), a major fatty acid (FA) component of royal jelly, is synthesized in the mandibular glands (MGs) of worker honeybees.
Yunchang Li, Xiaojing Zhang, Zhenyu Xia, Yue Hao   +3 more
doaj   +2 more sources

10-HDA, A Major Fatty Acid of Royal Jelly, Exhibits pH Dependent Growth-Inhibitory Activity Against Different Strains of Paenibacillus larvae [PDF]

Molecules, 2018
Paenibacillus larvae (P. larvae) is a bacterial pathogen causing American foulbrood (AFB), the most serious disease of honeybee larvae. The food of young larvae could play an important role in the resistance of larvae against AFB.
Mária Šedivá, Maroš Laho, Lenka Kohútová, Andrea Mojžišová, Juraj Majtán, Jaroslav Klaudiny   +5 more
doaj   +2 more sources

10-Hydroxy-2-decenoic Acid Suppresses Colorectal Cancer Progression by Inhibiting Wnt/β-Catenin Signaling and Promoting Apoptosis [PDF]

Foods
Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide, and advanced disease continues to show poor prognosis due to therapeutic limitations and drug resistance.
Yan Lin, Rongjing Cai, Lei Huang, Tianxing Lin, Anqi Lin, Zhenyu Lin, Shoujie Jiang, Yuqi Zhu, Yuan Yuan, Songkun Su   +9 more
doaj   +2 more sources

Alteration of Subchondral Bone Density Distribution Across the Knee Joint Before and After Anterior Cruciate Ligament Reconstruction [PDF]

Orthopaedic Journal of Sports Medicine
Background: Anterior cruciate ligament (ACL) injury alters knee kinematics and contact mechanics, increasing posteromedial (PM) loading and the risk of knee osteoarthritis.
Taku Ebata MD, PhD, Koji Iwasaki MD, PhD, Dai Sato MD, PhD, Masatake Matsuoka MD, PhD, Tomohiro Onodera MD, PhD, Eiji Kondo MD, PhD, Norimasa Iwasaki MD, PhD   +6 more
doaj   +2 more sources

Closed-Set Heterogeneous Domain Adaptation for IoT Intrusion Detection: An Anchor-Based Benchmark Across Single- and Multi-Source Transfer [PDF]

Sensors
Closed-set heterogeneous domain adaptation (HDA) for Internet of Things (IoT) intrusion detection aims to transfer detection capabilities across environments that differ in devices, telemetry, feature schemas, attack implementations, label taxonomies ...
Mohammad Chizari, Qublai Khan Ali Mirza, Abu Alam, Hassan Chizari   +3 more
doaj   +2 more sources

Novel involvement of LMTK2 and EML6 in rheumatoid arthritis: potential biomarkers for disease activity and seronegative patients [PDF]

Frontiers in Immunology
IntroductionRheumatoid arthritis (RA) is a chronic, multifactorial autoimmune disease characterized by symmetrical polyarthritis, joint pain, and swelling, which can lead to disability and premature death.
Hubert Kubis, Marek Cieśla, Anna Pałka, Bogdan Kolarz   +3 more
doaj   +2 more sources