Results 61 to 70 of about 134,957 (281)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

YIELD AND QUALITY OF JUTE SEED AS INFLUENCED BY VARIETY AND SOWING DATE AT LATE SOWN CONDITION [PDF]

, 2021
A Thesis submitted to the Institute of Seed Technology, Sher-e-Bangla Agricultural University, Dhaka in partial fulfilment of the requirements for the degree of MASTER OF SCIENCE (MS) IN SEED TECHNOLOGYThe research work was conducted in the ...
SHAMMI, IKRA HAQUE
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Genetic control over characteristic of 1000 seeds weight in hybrids of sugar beet and combining ability of crossbreeding components

Plant varieties studying and protection, 2012
Наведено експериментальні дані міжлінійних гібридів буряка цукрового за ознакою маса 1000 насінин, визначена генетична детермінація ознаки на основі методу Хеймана і топкросних багатотестерних схрещувань, проведено їхне порівняння. Виділено цінні гібридні комбінації і комбінаційно-цінні лінії-запилювачі, що використовуються у селекційному процесі при ...
openaire   +5 more sources

اثر تنش خشکی و محلول پاشی سولفات روی بر عملکرد و اجزای عملکرد آفتابگردان (Helianthus.annuus L.) [PDF]

تنش های محیطی در علوم زراعی, 2012
ایران جزء مناطق خشک و نیمه خشک به شمار می‌رود و از نظر آب و هوایی تنوع زیادی دارد، شناخت ویژگی‌های مربوط به رشد و عملکرد و نیز سازگاری آفتابگردان، به خصوص در رابطه با تنش خشکی می‌تواند در گسترش سطح زیر کشت و نیز افزایش عملکرد آن تأثیر مهمی داشته باشد.به ...
زهره بنی عباس شهری, غلامرضا زمانی, محمد حسن سیاری زهان   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

COMBINING ABILITY ANALYSIS FOR STRAW, SEED YIELDS AND THEIR COMPONENTS IN FLAX. [PDF]

Journal of Plant Production, 2003
This study was conducted with the objective of estimating combining ability and gene action for straw and seed yields and their components in flax. This was achieved via evaluating six parents {P1(Giza 7), P2(Giza 8), P3(S.329/2/23/6), P4(S.402/3/3/10 ...
Afaf Zahana,
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effect of seed weight and biostimulant seed treatment on establishment, growth and yield parameters of winter oilseed rape

This study evaluated the effect of seed weight and seed treatment on yield and growth parameters in a three-year field trial. Seed weight treatments were tested in three levels of thousand seed weight (TSW): low 4.28 g, medium 5.00 g and high 5.69 g ...
Kateřina Pazderů, Matěj Satranský, David Bečka, Lucie Bečková   +3 more
core   +1 more source