Results 51 to 60 of about 134,957 (281)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The effect of foliar fertilization on yield and 1000 seed weight of soybean [PDF]

, 2018
U cilju sagledavanja uticaja folijarne prihrane na prinos i masu 1000 zrna soje, postavljen je dvogodišnji ogled na parcelama Instituta za ratarstvo i povrtarstvo na Rimskim Šančevima.
Valan, Dragana, Ilić, Aleksandar, Đukić, Vojin, Merkulov-Popadić, Larisa, Miladinov, Zlatica, Čobanović, Lazar, Ranđelović, Predrag   +6 more
core  

The alimentary impact of the hemp seed [PDF]

, 2013
Hemp seed and hemp seed oil can supply us with many important substances. Their essential fatty acid compositions are favourable, but they may contain non-psychotropic cannabinoids. Emerging data show that these components can influence the health status
Ditrói, Kálmán, Böszörményi, Andrea, K. Ditrói, Fébel, H., Böszörményi, A., Kleiner, D., Szentmihályi, K., A. Böszörményi, Kleiner D,, D. Kleiner, Szentmihályi, Klára, Ditrói, K., K. Szentmihályi, H. Fébel, Fébel, Hedvig   +14 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The linear regression between weight of 1000 seeds and seed coat for analysed genotypes Lupinus angustifolius.

, 2014
The linear regression between weight of 1000 seeds and seed coat for analysed genotypes Lupinus angustifolius.
Bartosz Kozak (614687), Dariusz Jan Michalczyk (614688), Stanislaw Stawiński (614691), Dariusz Zalewski (614692), Ewa Sawicka-Sienkiewicz (614690), Renata Galek (614686), Agnieszka Iwona Piotrowicz-Cieślak (614689), Jon Clements (614685)   +7 more
core   +1 more source

Correlations and distribution of grain yield, 1000 seed weight, total water-soluble carbohydrates, and protein concentration among the genotypes grown under organic field conditions.

, 2022
Correlations and distribution of grain yield, 1000 seed weight, total water-soluble carbohydrates, and protein concentration among the genotypes grown under organic field conditions.
Joshua Kay (8358612), Emerson Shipe (1397452), Shiv Kumar (634406), Rebecca McGee (3547916), Tristan J. Lawrence (11944341), Dil Thavarajah (9671780), Sarah E. Powers (11944344), Rick Boyles (11944350), Pushparajah Thavarajah (11944347)   +8 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Storability of some Oil Seed Crops Under Two Types of Packages [PDF]

Journal of Plant Production, 2016
          Effect of storability on germination, viability and chemical composition of sunflower (Sakha53), canola (Sero4) and sesame seeds (Shandwel3 and Giza32) was the aim of this study was contacted at the Seed Technology Research of  Sakha, Agric ...
Amany Mohamed, Alaa Shahein
doaj   +1 more source

Effect of seed and seed lot 1000‐seed weight on vegetative and reproductive yields of ‘Grasslands Moata’ tetraploid Italian ryegrass ( Lolium multiflorum ) [PDF]

New Zealand Journal of Crop and Horticultural Science, 1986
Abstract Increasing 1000‐seed weight, both between and within seed lots of Grasslands Moata' tetraploid Italian ryegrass ( Lolium multiflorum Lam.), increased seedling growth, emergence at 5 and 10°C, and vigour.
openaire   +1 more source