Results 71 to 80 of about 134,957 (281)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Yield and quality of carrot seeds, cv. Brasília, as a result of plant population, gibberellic acid and stage of maturity

open access: yes, 2004
'Brasília' is a cultivar of carrot with characteristics suiting cultivation under hot conditions but with problems in seed production, arising from the conflicting requirements of root and seed production.
Barbedo, A. S.C.   +4 more
core   +1 more source

Effect of Plant Density on Yield and Yield Seed Components of Rapeseed (Brassica napus) Cultivars [PDF]

open access: yesIkufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2013
To study the effects of different plant density on seed yield and yield components of three spring rapeseed cultivars a factorial experiment based on a Randomized Complete Block Design with three replications and 9 treatments was carried out during 2011 ...
M. Matinfar   +4 more
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

INFLUENCE OF ORGANIC MANURE, PHOSPHORUS - POTASSIUM ON GROWTH, YIELD AND SEED QUALITY OF BLACKGRAM [PDF]

open access: yes, 2021
A Thesis Submitted to the Institute of seed technology Sher-e-Bangla Agricultural University, Dhaka, in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE (MS) IN SEED TECHNOLOGYA pot experiment was conducted at the ...
AKTER, SHARMIN
core  

Relation between fruit weight and seed number in eggplant fruit: Seed number = 1691.44 - (145373/ Fruit weight).

open access: yes, 2023
Relation between fruit weight and seed number in eggplant fruit: Seed number = 1691.44 - (145373/ Fruit weight).
Daniel N. Peraza (14504530)   +3 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Heterosis and variability studies for yield and yield components traits in pearl millet [Pennisetum glaucum (L.) R. Br.]

open access: yesElectronic Journal of Plant Breeding, 2017
The experiment was conducted to study the heterosis and variability parameters by using 41 hybrids along with a check during kharif 2015. The per se performance and standard heterosis revealed that the hybrids viz., NHB 999, NPH-5286, AHB-1157 and 86M90 ...
P. Sumathi and, S. Revathi
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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