Results 31 to 40 of about 397,822 (261)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessing University Contributions to Sustainability in Europe: A Data-Driven Analysis of SDG 12 (Responsible Consumption) and SDG 13 (Climate Action)

World
With intensifying demands for sustainability in higher education—particularly tied to the United Nations’ Sustainable Development Goals (SDGs)—universities remain central to fostering responsible consumption and climate action. However, a significant gap
Lena Malešević Perović, Maja Mihaljević Kosor, Nikša Alfirević   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Responsible consumption and production as 12th sustainable development goal: a commentary on Pakistani students green entrepreneurship orientation [PDF]

Journal of Responsible Production and Consumption
PurposeDespite the discussion among scholars on green entrepreneurship and sustainable development, little is known regarding the role of responsible consumption and production implementation, which is the 12th goal among the sustainable development ...
Muhammad Murad
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Advancing Sustainable Development Through Circularity Metrics: A Comprehensive Indicator Framework for Assessing Progress on SDG 12 Across Sectoral Drivers

Resources
This study provides an integrated assessment of progress toward Sustainable Development Goal 12 (Responsible Consumption and Production) by applying a multivariate, indicator-based framework to a comprehensive set of EU-27 performance metrics.
Ionela Gavrila-Paven, Ramona Giurea, Elena Cristina Rada   +2 more
doaj   +1 more source

Sustainable Fashion Principle-Based Multifunctional Clothing [PDF]

E3S Web of Conferences
The rapid growth of the fashion industry has intensified environmental pressures, including excessive textile waste, high resource consumption, and increasing carbon emissions.
Listiani Sri, Suryawati, Zahra E. Lutfia
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Regional dynamics of precision agriculture adoption and knowledge transfer: Insights from Georgia extension agents

Advancements in Agricultural Development
The Cooperative Extension System plays a vital role in disseminating innovative knowledge from the University to public decision makers. However, there is a lack of studies on the dynamics of knowledge transfer from Extension agents to farmers ...
Ginger Orton, Chin-Ling Lee
doaj   +1 more source