Erythropoietin messenger RNA levels in developing mice and transfer of 125I-erythropoietin by the placenta. [PDF]
Journal of Clinical Investigation, 1988 Erythropoietin (EP) mRNA was measured in normal and anemic mice during fetal and postnatal development. Normal fetal livers at 14 d of gestation contained a low level of EP mRNA. By day 19 of gestation, no EP mRNA was detected in normal or anemic fetal livers or normal fetal kidneys, but anemic fetal kidneys had low levels of EP mRNA.
M J, Koury +3 more
exaly +5 more sources
Synthesis and biological evaluation of 125I-erythropoietin as a potential radiopharmaceutical agent for tumours [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2011 Erythropoietin (EPO) is a glycoprotein hormone responsible for regulating erythropoiesis. Expression of EPO and EPO receptors (EPOr) has recently been demonstrated in some neoplastic cell lines and tumours, suggesting a potential new target for therapy ...
Gonçalo dos Santos Clemente +1 more
doaj +8 more sources
A dot assay for the erythropoietin receptor using human recombinant 125I-erythropoietin
Analytical Biochemistry, 1989 A dot assay was developed for the detection of membrane receptor(s) for erythropoietin (Ep). A relatively homogeneous population of cells bearing the receptor for Ep was generated in the spleen of mice made anemic with phenylhydrazine and crude membrane extracts were prepared from spleen cell suspensions.
VANNUCCHI, ALESSANDRO MARIA +4 more
exaly +5 more sources
Erythropoietin promoted the proliferation of hepatocellular carcinoma through hypoxia induced translocation of its specific receptor [PDF]
Cancer Cell International, 2017 Background Erythropoietin (EPO) is a hypoxia-inducible stimulator of erythropoiesis. Besides its traditional application in anemia therapy, it offers an effective treatment in the cancer patients, especially those who receive chemotherapy.
Shuo Miao +8 more
doaj +2 more sources
Binding of recombinant human 125I-erythropoietin to CFU-E from the spleen of anemic mice.
Haematologica, 1990 Erythroid precursors were obtained from the spleen of mice made anemic with phenylhydrazine and used to study the binding of bioactive 125I-rEp to membrane receptors. Kinetic analysis, using splenic cells obtained at different times following the induction of anemia, showed that the maximum binding was reached at day 3, and decreased thereafter ...
VANNUCCHI, ALESSANDRO MARIA +4 more
openaire +3 more sources
Platelet derived growth factor receptor alpha is essential for establishing a microenvironment that supports definitive erythropoiesis [PDF]
, 2006 金沢大学大学院自然科学研究科大阪大学微生物病研究所 情報伝達分野The hematopoietic system undergoes a qualitative change during the embryogenesis of most vertebrates. It is designated as the shift of primitive to definitive hematopoiesis and suitable microenvironment must be established
Li Wen-Ling +5 more
core +2 more sources
Hypoxia and its Emerging Therapeutics in Neurodegenerative, Inflammatory and Renal Diseases [PDF]
, 2017 Hypoxia is a common underlying condition of many disease states. Hypoxia can occur with ischemia, a lack of blood flow to tissues, or independent of ischemia as in acute lung injury, anemia, and carbon monoxide poisoning.
Ardekani, Mohammad Sanaei +3 more
core +1 more source
Dynamics of erythropoietin receptor expression on erythropoietin- responsive murine cell lines [PDF]
, 1990 We examined erythropoietin receptor expression in two murine cell lines, B6SUtA and DA-1, that respond to erythropoietin in different ways. While B6SUtA cells undergo erythroid differentiation with limited proliferation after addition of erythropoietin ...
B Nakamoto +3 more
core +3 more sources
KU 812: a pluripotent human cell line with spontaneous erythroid terminal maturation [PDF]
, 1989 A human leukemic cell line KU 812 was recently established and described as a basophilic cell line. In the present study we show that KU 812 and two of its clones are at least bipotent: in addition to a minor component of basophils, the majority of KU ...
A Dubart +9 more
core +3 more sources
Studies on the specificities of In Vivo and In Vitro bioassays used in the potency determination of Therapeutic Erythropoietin [PDF]
, 2006 Erythropoietin (Epo), a kidney-produced cytokine, promotes the proliferation and differentiation of erythroid progenitors into mature red blood cells.The in vivo biological activity of Epo is dependent on it being adequately glycosylated.
Liefooghe, Emily Claire
core +1 more source