Results 11 to 20 of about 675 (80)

Independent risk factors of rapid glomerular filtration rate decline in patients with type 2 diabetes with preserved kidney function and normoalbuminuria: A multicenter cohort study. [PDF]

J Diabetes Investig, 2023
We conducted a retrospective cohort study of patients with type 2 diabetes with preserved renal function and normoalbuminuria, with and without rapid decliners, to investigate the involvement of the baseline hemoglobin level as a potential predictor of rapid renal function decline.
Hirano D, Unoki-Kubota H, Imasawa T, Yamamoto-Honda R, Kajio H, Yamashita S, Fukazawa Y, Seki N, Noda M, Kaburagi Y.   +9 more
europepmc   +2 more sources

Haemodynamic, hormonal and renal actions of osteocrin in normal sheep. [PDF]

Exp Physiol
Abstract Osteocrin (OSTN) is an endogenous protein sharing structural similarities with the natriuretic peptides [NPs; atrial (ANP), B‐type (BNP) and C‐type (CNP) NP], which are hormones known for their crucial role in maintaining pressure/volume homeostasis. Osteocrin competes with the NPs for binding to the receptor involved in their clearance (NPR‐C)
Scott NJA, Prickett TCR, Charles CJ, Espiner EA, Richards AM, Rademaker MT.   +5 more
europepmc   +2 more sources

Serum gastrin concentrations in dogs with primary hyperparathyroidism. [PDF]

J Vet Intern Med
Abstract Background Hypercalcemia has been associated with hypergastrinemia in humans. Hypergastrinemia could be responsible for gastrointestinal (GI) signs in dogs with primary hyperparathyroidism (PHPT). Hypothesis/Objectives (a) Determine whether hypergastrinemia occurs in dogs with PHPT, (b) assess for potential correlations among ionized calcium ...
Vose J, Jaffey J, Akin C, Spitzer A, DeCicco B, Bassiouny E, LaClair A, Petroff B, Brudvig J, Cridge H.   +9 more
europepmc   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors

British Journal of Pharmacology, Volume 180, Issue S2, Page S241-S288, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Doris Koesling, Michaela Kuhn, David MacEwan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes‐Peter Stasch, Scott A. Waldman   +27 more
wiley   +1 more source

Emerging nanoprobes for the features visualization of vulnerable atherosclerotic plaques. [PDF]

Smart Med
The pathophysiology of atherosclerosis and the rational design principle of nanoprobes for the feature visualization of vulnerable atherosclerotic plaques are introduced. In addition, the nanoprobes for the feature visualization of vulnerable atherosclerotic plaques are discussed. Abstract Atherosclerosis (AS) is a major cause of cardiovascular disease.
Wang X, Mu D, Liang J, Xin R, Zhang Y, Liu R, Yao M, Zhang B.   +7 more
europepmc   +2 more sources

Effects of the sodium-glucose co-transporter-2 inhibitor dapagliflozin on estimated plasma volume in patients with type 2 diabetes. [PDF]

Diabetes Obes Metab, 2019
Abstract Aims To compare the effects of the sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor dapagliflozin on estimated (ePV) and measured plasma volume (mPV) and to characterize the effects of dapagliflozin on ePV in a broad population of patients with type 2 diabetes.
Dekkers CCJ, Sjöström CD, Greasley PJ, Cain V, Boulton DW, Heerspink HJL.   +5 more
europepmc   +2 more sources

Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy

Journal of Pineal Research, Volume 72, Issue 1, January 2022., 2022
Abstract Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal treatment with melatonin protects against programmed cardiovascular dysfunction in the offspring using an established rodent model of hypoxic pregnancy. Wistar rats were divided
Jeremy A. Hansell, Hans G. Richter, Emily J. Camm, Emilio A. Herrera, Carlos E. Blanco, Eduardo Villamor, Olga V. Patey, Mitchell C. Lock, Andrew W. Trafford, Gina L. J. Galli, Dino A. Giussani   +10 more
wiley   +1 more source

When hemolysis masks polycythemia vera. [PDF]

Clin Case Rep, 2019
Although uncommon, clinicians should be aware that polycythemia vera may be masked due to hemolysis. The report of such associations could help them in clinical practice to establish an early and accurate diagnosis that may be challenging in atypical presentations of myeloproliferative neoplasms.
Derrieux C, Jeandel R, Martin A, Dosquet C, Cassinat B, Fouillard L.   +5 more
europepmc   +2 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors

British Journal of Pharmacology, Volume 178, Issue S1, Page S264-S312, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Michaela Kuhn, David MacEwan, Tom P. Monie, Lincoln R. Potter, Harald H.H.W. Schmidt, Scott A. Waldman   +26 more
wiley   +1 more source

Association of estimated plasma volume and weight loss after long‐term administration and subsequent discontinuation of the sodium‐glucose cotransporter‐2 inhibitor tofogliflozin

Diabetes, Obesity and Metabolism, Volume 23, Issue 7, Page 1660-1665, July 2021., 2021
Abstract Sodium‐glucose cotransporter‐2 inhibitors (SGLT2) are drugs that have been reported to have several effects through the regulation of plasma volume, for example, antihypertensive effects. This study aimed to clarify the impact of long‐term administration and subsequent discontinuation of the SGLT2 inhibitor tofogliflozin on estimated plasma ...
Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone   +10 more
wiley   +1 more source