Results 41 to 50 of about 1,287,896 (282)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Behavioural drivers and barriers for adopting climate mitigation actions on dairy farms

Advancements in Agricultural Development
The adoption of climate mitigation actions on farms has the potential to lessen the effects of climate change on agriculture. The purpose of this study is to identify the behavioural drivers and barriers for adopting climate mitigation actions on dairy ...
Niamh Dunphy, Seamus Kearney, Sinéad Flannery   +2 more
doaj   +1 more source

The central role of climate action in achieving the United Nations' Sustainable Development Goals

Scientific Reports, 2023
Sustainable Development Goal (SDG) 13 refers to “Climate Action”. It is one of the 17 goals established by the United Nations in their 2030 Agenda for Sustainable Development.
Walter Leal Filho, Tony Wall, Amanda Lange Salvia, Maria Alzira Pimenta Dinis, Mark Mifsud   +4 more
doaj   +1 more source

Achieving food security in the face of climate change: Final report from the Commission on Sustainable Agriculture and Climate Change [PDF]

, 2014
To bring our interconnected food and climate systems within a ‘safe operating space’ for people and the planet, the Commission on Sustainable Agriculture and Climate Change has outlined seven major areas for policy action. Throughout 2011, the Commission
Asaduzzaman, Mohammed, Beddington, J.R., Bo, NV, Clark, Megan E., Erda, Lin, Fernández, A., Guillou, Marion, Jahn, Molly M., Mamo, Tekalign, Nobre, Carlos A., Scholes, Robert J., Sharma, Rita, Wakhungu, Judi W.   +12 more
core  

A Comparative Analysis of Initiatives and Adaptation Measures to Climate Change Undertaken in Poland and Western Europe [PDF]

, 2016
The analysis of the main initiatives for adaptation to climate change in selected countries of Western Europe and Poland relate to key issues mentioned in the strategic documents of the European Commission.
Michalak, Dorota
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Decarbonisation of manufacturing operations: a case study in automotive manufacturing

Production and Manufacturing Research: An Open Access Journal
In response to the climate crisis, companies are increasingly committed to lowering their emissions. Previous studies have investigated climate mitigation strategies in carbon-intensive industries.
Andreas Serino Olander, Lucas Albuquerque Wolf, Lena Moestam, Mélanie Despeisse   +3 more
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Social media enables people-centric climate action in the hard-to-decarbonise building sector

Scientific Reports, 2022
The building and construction sector accounts for around 39% of global carbon dioxide emissions and remains a hard-to-abate sector. We use a data-driven analysis of global high-level climate action on emissions reduction in the building sector using 256 ...
Ramit Debnath, Ronita Bardhan, Darshil U. Shah, Kamiar Mohaddes, Michael H. Ramage, R. Michael Alvarez, Benjamin K. Sovacool   +6 more
doaj   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source