Results 121 to 130 of about 38,521 (297)

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source

13C-metabolic flux analysis of ethanol-assimilating Saccharomyces cerevisiae for S-adenosyl-l-methionine production

Microbial Cell Factories, 2018
Background Saccharomyces cerevisiae is a host for the industrial production of S-adenosyl-l-methionine (SAM), which has been widely used in pharmaceutical and nutritional supplement industries. It has been reported that the intracellular SAM content in S.
Kenshi Hayakawa, Fumio Matsuda, Hiroshi Shimizu   +2 more
doaj   +1 more source

FluxSimulator: An R Package to Simulate Isotopomer Distributions in Metabolic Networks [PDF]

The representation of biochemical knowledge in terms of fluxes (transformation rates) in a metabolic network is often a crucial step in the development of new drugs and efficient bioreactors.
Ivo H. M. van Stokkum, Jaap Heringa, Johannes H. G. M. van Beek, Katharine M. Mullen, Thomas W. Binsl   +4 more
core   +1 more source

A Cascade Recognition of Activatable Probe for Fluorescence Navigation Glioblastoma Surgery: Overcoming Blood‐Brain Barrier and Off‐Target Limitations

Advanced Science, EarlyView.
A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An, Yu Guo, Yongning Bian, Yanli Tan, Chuan Fang, Hengzhu Zhang, Xueqian Chen, Lin Yuan, Dongdong Su   +8 more
wiley   +1 more source

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

Sugar‐Armored Pesticides: Self‐Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases

Advanced Science, EarlyView.
This study develops a sugar‐armored, self‐assembled pesticide delivery system that enhances foliar adhesion, provides sustained release, effectively disrupts biofilms, and demonstrates superior bactericidal activity for improved disease control.
Jinghan Yang, Juan Liu, Xiaohui Wang, Peiyi Wang   +3 more
wiley   +1 more source

Systematic evaluation of methods for integration of transcriptomic data into constraint-based models of metabolism.

PLoS Computational Biology, 2014
Constraint-based models of metabolism are a widely used framework for predicting flux distributions in genome-scale biochemical networks. The number of published methods for integration of transcriptomic data into constraint-based models has been rapidly
Daniel Machado, Markus Herrgård
doaj   +1 more source

Dispensability of Escherichia coli's latent pathways

, 2011
Gene-knockout experiments on single-cell organisms have established that expression of a substantial fraction of genes is not needed for optimal growth.
A. E. Motter, Baba, Barab  si, Becker, Blank, Braunstein, Covert, Deluna, Deutscher, Edwards, Emmerling, Feist, Feist, Ferguson, Flores, Fong, Fong, Freilich, Gerdes, Giaever, Goyal, Gu, Hasona, Herring, Hillenmeyer, Hopkins, Hua, Ibarra, Ito, J. S. Lee, Kaufman, Klipp, Kupiec, Mahadevan, Motter, Motter, Nishikawa, Papp, Reed, Reed, S. P. Cornelius, Shi, Smith, Stern, Vinopal, Wagner   +45 more
core   +2 more sources

Time‐Dependent Recovery of Gastric Emptying After Gastrectomy: A 12‐Month Longitudinal Study Using a 13C‐Acetate Breath Test With a Semi‐Solid Meal

Annals of Gastroenterological Surgery, EarlyView.
This study examined time‐dependent changes in gastric emptying after gastrectomy for gastric cancer using a 13C‐acetate breath test with a semi‐solid meal in 95 patients, revealing that gastric emptying was initially delayed at 1 month but significantly accelerated by 12 months postoperatively.
Sachiko Kaida, Katsushi Takebayashi, Mika Kurihara, Reiko Otake, Haruki Mori, Hiromitsu Maehira, Toru Miyake, Shigeki Bamba, Masaji Tani   +8 more
wiley   +1 more source

Análisis cuantitativo y modelización del metabolismo de la levadura Pichia pastoris [PDF]

, 2008
Consultable des del TDXTítol obtingut de la portada digitalitzadaEl presente trabajo está centrado en el análisis y modelización del metabolismo central de la levadura Pichia pastoris.
Santos de Jesus, Sérgio
core   +3 more sources