Results 251 to 260 of about 38,521 (297)

Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss. [PDF]

NPJ Dement
Irmen RE, Turner SM, Snipes JA, Schloss KH, Wang X, Williams HC, Velmurugan GV, Hunt JB, Li J, Sullivan PG, Lee DC, Bauer AQ, Johnson LA, Macauley SL.   +13 more
europepmc   +1 more source

VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for Mycobacterium tuberculosis Virulence

Pascoe J, Newcombe J, Mendoza J, Birua S, Mendum TA, Anand K, Singh A, Sinha A, Papavinasasundaram K, Bhatt A, Larrouy-Maumus G, Singh A, Goulding CW, Beste DJ.   +13 more
europepmc   +1 more source

GC–QTOFMS with a low-energy electron ionization source for advancing isotopologue analysis in 13C-based metabolic flux analysis

Analytical and Bioanalytical Chemistry, 2019
For the study of different levels of (intra)cellular regulation and condition-dependent insight into metabolic activities, fluxomics experiments based on stable isotope tracer experiments using 13C have become a well-established approach. The experimentally obtained non-naturally distributed 13C labeling patterns of metabolite pools can be measured by ...
Teresa Mairinger, Jennifer Sanderson, Stephan Hann   +2 more
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Overcoming the metabolic burden of protein secretion in Schizosaccharomyces pombe – A quantitative approach using 13C-based metabolic flux analysis

Metabolic Engineering, 2014
Protein secretion in yeast is generally associated with a burden to cellular metabolism. To investigate this metabolic burden in Schizosaccharomyces pombe, we constructed a set of strains secreting the model protein maltase in different amounts. We quantified the influence of protein secretion on the metabolism applying (13)C-based metabolic flux ...
Tobias Klein, Sabrina Lange, Nadine Wilhelm, Matthias Bureik, Tae-Hoon Yang, Elmar Heinzle, Konstantin Schneider   +6 more
openaire   +3 more sources

13C-Based Metabolic Flux Analysis of Recombinant Pichia pastoris

Methods in molecular biology, 2014
Overexpression of a foreign protein may negatively affect several cell growth parameters, as well as cause cellular stress. Central (or core) metabolism plays a crucial role since it supplies energy, reduction equivalents, and precursor molecules for the recombinant product, cell's maintenance, and growth needs.
Pau Ferrer, Joan Albiol
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13C-Based Metabolic Flux Analysis: Fundamentals and Practice

Methods in molecular biology, 2013
Isotope-based metabolic flux analysis is one of the emerging technologies applied to system level metabolic phenotype characterization in metabolic engineering. Among the developed approaches, (13)C-based metabolic flux analysis has been established as a standard tool and has been widely applied to quantitative pathway characterization of diverse ...
T. Yang
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13C-based metabolic flux analysis of Saccharomyces cerevisiae with a reduced Crabtree effect

Journal of Bioscience and Bioengineering, 2015
Shuichi Kajihata, Fumio Matsuda, Mika Yoshimi, Kenshi Hayakawa, Chikara Furusawa, Akihisa Kanda, Hiroshi Shimizu   +6 more
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13C-Based Metabolic Flux Analysis in Yeast: The Pichia pastoris Case

Methods in molecular biology, 2014
Pau Ferrer, Joan Albiol
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High-Throughput Stationary 13C-Based Metabolic Flux Analysis of Pichia pastoris Strains

Methods in molecular biology
Albert Fina, Pierre Millard, Cecilia Berges, Pau Ferrer, Joan Albiol, Stéphanie Heux   +5 more
openaire   +2 more sources