Results 261 to 270 of about 38,521 (297)

Evaluation of isotope discrimination in 13C-based metabolic flux analysis

Analytical Biochemistry, 2011
In a (13)C experiment for metabolic flux analysis ((13)C MFA), we examined isotope discrimination by measuring the labeling of glucose, amino acids, and hexose monophosphates via mass spectrometry. When Escherichia coli grew in a mix of 20% fully labeled and 80% naturally labeled glucose medium, the cell metabolism favored light isotopes and the ...
Xueyang, Feng, Yinjie J, Tang
openaire   +2 more sources

Abstract 1160: A machine learning based method for in-vivo metabolic flux analysis of patient tumors

Cancer Research, 2023
Metabolic fluxes likely control cancer phenotypes and treatment responses but cannot be measured in cancers in human patients. Machine learning has become a popular tool to study cancer biology and can identify complex patterns in the data which may ...
Anjali Mittal, A. Scott, Abhinav Achreja, V. Tarnal, W. Al-Holou, C. Lyssiotis, D. Wahl, Deepak Nagrath   +7 more
semanticscholar   +1 more source

Physiological characterization of recombinant Saccharomyces cerevisiae expressing the Aspergillus nidulans phosphoketolase pathway: validation of activity through 13C-based metabolic flux analysis

Applied Microbiology and Biotechnology, 2012
Several bacterial species and filamentous fungi utilize the phosphoketolase pathway (PHK) for glucose dissimilation as an alternative to the Embden-Meyerhof-Parnas pathway. In Aspergillus nidulans, the utilization of this metabolic pathway leads to increased carbon flow towards acetate and acetyl CoA. In the first step of the PHK, the pentose phosphate
Marta Papini, Intawat Nookaew, Verena Siewers, Jens Nielsen   +3 more
openaire   +2 more sources

Peer Review #2 of "13C based proteinogenic amino acid (PAA) and metabolic flux ratio analysis of Lactococcus lactis reveals changes in pentose phosphate (PP) pathway in response to agitation and temperature related stresses (v0.1)"

2017
Lactococcus lactis subsp.cremoris MG1363 is an important starter culture for dairy fermentation.During industrial fermentations, L. lactis is constantly exposed to stresses that affect the growth and performance of the bacterium.Although the response of L.
Kamalrul Azlan Azizan, Habtom W. Ressom, Eduardo Mendoza, Syarul Nataqain, Baharum Corresp, Syarul Nataqain Baharum   +5 more
openaire   +1 more source

13C isotope-based metabolic flux analysis revealing cellular landscape of glucose metabolism in human liver cells exposed to perfluorooctanoic acid.

Science of the Total Environment, 2021
Ruijia Zhang, Baowei Chen, Li Lin, Hui Zhang, Tiangang Luan   +4 more
semanticscholar   +1 more source

Dual strategy for 13C-Metabolic flux analysis of central carbon and energy metabolism in Mammalian cells based on LC-isoMRM-MS.

Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2023
Jie Zheng, Junjie Yang, Xu Liang, M. Fang, Yulan Wang   +4 more
semanticscholar   +1 more source

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Nature Reviews Microbiology, 2022
Stephanie Collins, Andrew D Patterson
exaly  

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature Reviews Clinical Oncology, 2022
Neil Vasan, Lewis C Cantley
exaly  

Estimation of linear and cyclic electron flows in photosynthesis based on 13C-metabolic flux analysis.

Journal of Bioscience and Bioengineering, 2020
C. Yamamoto, M. Toyoshima, Sayaka Kitamura, Y. Ueno, S. Akimoto, Yoshihiro Toya, H. Shimizu   +6 more
semanticscholar   +1 more source

[Construction and application of natural stable isotope correction matrix in 13C-labeled metabolic flux analysis].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2022
Shiyuan Zheng, Junfeng Jiang, Jianye Xia
semanticscholar   +1 more source