Results 71 to 80 of about 12,503,962 (333)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

On Crystal Mosaicity in Single Crystal Ni-Based Superalloys

Crystals, 2019
In the present work, we investigate the evolution of mosaicity during seeded Bridgman processing of technical Ni-based single crystal superalloys (SXs).
Philipp Hallensleben, Felicitas Scholz, Pascal Thome, Helge Schaar, Ingo Steinbach, Gunther Eggeler, Jan Frenzel   +6 more
doaj   +1 more source

Critical phenomena: 150 years since Cagniard de la Tour

, 2009
Critical phenomena were discovered by Cagniard de la Tour in 1822, who died 150 years ago. In order to mark this anniversary, the context and the early history of his discovery is reviewed.
A Haupt, A Thomy, A.-L Lavoisier, A.B Zamolodchikov, Andrews T., C Cagniard de la Tour, C Cagniardde la Tour, C Domb, D.I Mendeleev, E Ising, Faraday M, J.D van der Waals, L.D Landau, M Barmatz, M Faraday, M Faraday, M Faraday, N.C Metropolis, P Curie, W Lenz, William F Clay, William F. Clay, Y Goudaroulis   +22 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Quelles techniques pour végétaliser des enrochements de berges de cours d’eau ? [PDF]

Sciences, Eaux & Territoires, 2015
Les enrochements de berge de rivière constituent un pis-aller sur le plan environnemental et le génie végétal lui est préférable. Toutefois, lorsque les contraintes imposent d’avoir recours à des enrochements, il est préférable de les végétaliser pour ...
EVETTE, André, BAZ, Frank, CAVAILLÉ, Paul, FROSSARD, Pierre-André, FROSSARD, Pierre-André   +4 more
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Production   Practice of  150 mm×150 mm  Concasting Billet of Steel  ML08Al

Teshugang, 2006
The   low   carbon   low   silicon   aluminum   killed   steel   ML08Al(%:≤0.08C,0.20～0.50Mn,≤0.06Si,  0.02Al)was produced by 83 t top-bottom combined blown converter - 83 t ladle furnace - 6 strand 150 mmx 150 mm billet concaster process at Baotou Steel.
郭平, 郑颖, 石玉宏
doaj  

Large-Scale Histological Image Dataset with Metadata for Colorectal Cancer Microenvironment

Scientific Data
The pronounced heterogeneity of the tumor microenvironment (TME) in colorectal cancer (CRC) presents major obstacles in accurately predicting patient outcomes and tailoring treatment responses.
Hao Wang, Huiying Li, Jingmin Xue, Yang Jiang, Keru Ma, Fenqi Du, Genshen Mo, Hao Li, Yuze Huang, Haonan Xie, Hongxue Meng, Peng Han, Shenghan Lou   +12 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source