Results 51 to 60 of about 83,286 (224)

Importance of Entrepreneurs’ Knowledge for Business Restarts of Micro and Small Enterprises [PDF]

open access: yes, 2013
Przedstawiona publikacja jest poświęcona charakterystyce i znaczeniu restartów jako następstw niepowodzeń gospodarczych. Zjawisko to staje się coraz częściej wymieniane w kategorii badawczej.
Ropęga, Jarosław
core  

Museums in former residences: castles, palaces and manor houses [PDF]

open access: yes, 2009
The article concerns former residences in Poland and their contemporary use as museums. The authors present the history of Polish residences, the development of museums in castles, palaces and manor houses, their spatial distribution and the relations ...
Krakowiak, Beata, Latosińska, Jolanta
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Polish Interstate Relations with Ukraine, Belarus and Lithuania After 1990 in the Context of the Situation of National Minorities [PDF]

open access: yes, 2013
When we compare the contemporary ethnic structure and national policy of Poland and its eastern neighbours, we can see clear asymmetry in both quantitative and legal-institutional aspects.
Barwiński, Marek
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Universities of the Third Age in Poland. Emerging Model for 21st Century [PDF]

open access: yes, 2013
Main objective of this paper is to describe emergence of a Polish Universities of the Third Age model. These are a multidisciplinary non-formal education centers, which allow formation of positive responses to the challenges of an ageing population ...
Klimczuk, Andrzej
core   +4 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Three states, one common past: chance or malediction? The role of history and historiography in the formation of collective identities and mutual relations in Belarus, Lithuania and Poland [PDF]

open access: yes, 2008
Common experiences and a common past offer a special possibility for good relations. But having a common past also can create disharmony. If one has to share traditions with others, it becomes more difficult to find specific elements to call one’s ‘own’.
Ritter, R.
core  

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