Results 61 to 70 of about 1,724,626 (297)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Reformation in the burgh of St Andrews : property, piety and power
, 2014 This thesis examines the impact of the Reformation on the estates of ecclesiastical institutions and officials based in St Andrews. It argues that land and wealth were redistributed and power structures torn apart, as St Andrews changed from Scotland’s
Rhodes, Elizabeth
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Chloroquine degradation in aqueous solution under electron beam irradiation
NukleonikaPharmaceutically active compounds are the most widely produced and consumed consumer products that pose a substantial threat to the environment and living organisms owing to their pharmacokinetics, side effects, and contraindications.
Kabasa Stephen +3 more
doaj +1 more source
New Aspects of Resuscitation in Neurology and Neurosurgery
Общая реаниматология, 2014 The course of critical conditions in neurology and neurosurgery has specific features associated with the complex pathogen esis of brain injury, which in turn determines the specificity of resuscitation care.
K. A. Popugaev +2 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Degradation of hydroxychloroquine in aqueous solutions under electron beam treatment
NukleonikaHydroxychloroquine (HCQ), a 4-amino quinoline derivative, has antimalarial and anti-inflammatory activity and was most recently proposed in the treatment of SARS-COVID-19.
Kabasa Stephen +3 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source