Results 161 to 170 of about 564,067 (287)

Species-level profiling of <i>Landoltia punctata</i> (duckweed) microbiome under nutrient stress using full-length 16S rRNA sequencing. [PDF]

PeerJ
Bunyoo C, Phonmakham J, Morikawa M, Thamchaipenet A.   +3 more
europepmc   +1 more source

Term 16

Medical Mycology Journal, 2017
openaire   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Candida serves as a reservoir associating with facilitating the survival and pathogenesis of <i>Helicobacter pylori</i>. [PDF]

Front Microbiol
Sun J, Yang T, Luo Q, Wang Y, Zhang W, Chen Z.   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Molecular-based detection of Ehrlichia spp. in stray dogs-infesting Rhipicephalus ticks in high-altitude of northern Pakistan. [PDF]

PLoS One
Majid A, Numan M, Tila H, Liaqat I, Shah M, Sun Z, Ali A, Almutairi MM.   +7 more
europepmc   +1 more source

Comparison of five genotypic techniques for identification of optochin-resistant pneumococcus-like isolates [PDF]

, 2003
Claeys, Geert, De Baere, Thierry, De Ganck, Catharine Clara, KAIJALAINEN, T, Van Simaey, Leen, Vaneechoutte, Mario, Verhelst, Rita, Verschraegen, Gerda   +7 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Assessing anaerobe detection in routine sputum analyses from cystic fibrosis patients. [PDF]

Sci Rep
Clarenne A, Suarez LV, Muggeo A, Meurice J, Lecomte-Thenot Q, Perotin JM, Bessaci-Kabouya K, Mulette P, Abely M, Gouriou S, Dury S, Deslée G, Héry-Arnaud G, Guillard T.   +13 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source