Results 301 to 310 of about 191,806 (341)

Enzymatic Hydrolosis of 16s Ribosomal RNA and 30s Ribosomal Subunits

, 2020
openaire   +2 more sources

Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)‐associated tonsillar squamous cell carcinoma (TSCC)

International Journal of Cancer, EarlyView.
What's New? Human papillomavirus (HPV)‐associated tonsillar squamous cell carcinoma (TSCC) is suspected of originating from tonsillar crypts, where HPV can persist in latent form. Detection is further complicated by the possible absence of premalignant stages, namely carcinoma in situ (CIS). Here, the authors investigated tumor origin in HPV‐associated
Tobias Näsman, Madeleine Birgersson, Linda Marklund, Anders Näsman   +3 more
wiley   +1 more source

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

International Journal of Cancer, EarlyView.
What's New? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta, Marina Fujimoto, Yasuha Hiraoka, Aoi Taniguchi, Yuki Shiiba, Takuto Inoki, Tomoaki Yamauchi, Yuya Yoshida, Naoya Matsunaga, Shigehiro Ohdo, Satoru Koyanagi   +10 more
wiley   +1 more source

The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia

International Journal of Cancer, EarlyView.
Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch, Ana Carolina Rodrigues, Priscila Elias Ferreira Stricker, Alexandre Luiz Korte Azevedo, Daniel Pacheco Bruschi, Jaqueline Carvalho de Oliveira   +5 more
wiley   +1 more source

A Dual Action of Everolimus in Ulcerative Colitis: Blocking CLEC4E‐Driven Inflammation and Remodeling the Gut Microbiota‐Metabolite Axis

iMetaMed, EarlyView.
Graphical abstract of the major mechanisms of Everolimus in ulcerative colitis: Everolimus, a selective mTORC1 inhibitor, protects against ulcerative colitis through a dual mechanism. First, Eve directly suppresses CLEC4E/Syk/NF‐κB signaling, thereby reducing pro‐inflammatory cytokine production and preserving intestinal barrier integrity.
Jing Chen, Min Li, Wenyan Sun, Yuyun Chen, Yu Sheng, Cuihua Lu, Zhaoxiu Liu   +6 more
wiley   +1 more source

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Interaction of antibiotics with functional sites in 16S ribosomal RNA

Nature, 1987
Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of action of these antibiotics and for the ...
D, Moazed, H F, Noller
openaire   +3 more sources

Secondary Structure of 16 S Ribosomal RNA

Science, 1981
A secondary structure model for 16 S ribosomal RNA which is based on available chemical, enzymatic, and comparative sequence data shows good agreement between constraints dictated by the model and a wide variety of experimental observations.
H F, Noller, C R, Woese
openaire   +3 more sources

Nuclease S1 mapping of 16S ribosomal RNA in ribosomes

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1990
Escherichia coli 16S rRNA and 16S-like rRNAs from other species have several universally conserved sequences which are believed to be single-stranded in ribosomes. The quantitative disposition of these sequences within ribosomes is not known. Here we describe experiments designed to explore the availability of universal 16S rRNA sequences for ...
M A, Rahman, H W, Schaup
openaire   +2 more sources