Results 91 to 100 of about 109,607,141 (279)

Thermal Modelling of Metals and Alloys Irradiated by Pulsed Electron Beam: Focus on Rough, Heterogeneous and Multilayered Materials

Journal of Manufacturing and Materials Processing
Low-Energy High-Current Electron Beam (LEHCEB) is an innovative vacuum technology employed for the surface modification of conductive materials. Surface treatments by means of LEHCEB allow the melting and rapid solidification of a thin layer (up to ~10 ...
Andrea Lucchini Huspek, Valentina Mataloni, Ali Mohtashamifar, Luca Paterlini, Massimiliano Bestetti   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Additive Manufacturing Applications of 17-4 PH Material

Seçici lazer eritme (SLM) yöntemi, aynı zamanda lazer tabanlı toz yatak ergitme işlemi (LPBF) olarakda bilinen ve Al, Fe, Ti, Co, Cu ve Ni tabanlı alaşımlardan çeşitli geometrileri imal edebilen, en yaygınkullanılan eklemeli imalat yöntemlerinden ...
Türkyılmaz, Uğur Sıtkı, Karaağaç, İbrahim   +1 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Influence of Aging Treatment Regimes on Microstructure and Mechanical Properties of Selective Laser Melted 17-4 PH Steel. [PDF]

Micromachines (Basel), 2023
Dong D, Wang J, Chen C, Tang X, Ye Y, Ren Z, Yin S, Yuan Z, Liu M, Zhou K.   +9 more
europepmc   +1 more source

INFLUENCE OF DOUBLE SOLUTION TREATMENT ON HARDNESS IN 17-4 PH STEEL

JOURNAL OF ENGINEERING & PROCESSING MANAGEMENT, 2018
The investigated material is a corrosion-resistant, Cu precipitation hardened steel 17-4PH,which undergoes a macroscopic contraction, as a result of applying the following heat treatment:double solution treatment at 1028°C for 1 h (condition A), ageing at 540°C for 4 h (conditionH1025). The second solution treatment at 1028°C was found to eliminate the
R. Sowa, S. Arabasz, E. Roga, A. Dziedzic, I. Dul, A. Kowal, M. Parlinska-Wojtan   +6 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Acier 17-4 PH dans les réacteurs à eau légère : retour d’expérience

, 2016
L’acier 17-4 PH est utilisé avec succès depuis assez longtemps dans les réacteurs à eau légère. Ses propriétés intrinsèques obtenues par un durcissement par précipitation d’un acier inoxydable martensitique sont recherchées si l’on souhaite une ...
Chuck Marks, Gabriel Ilevbare, Jeff Gorman, Amanda Olender   +3 more
core   +1 more source

Research on the evolution of corrosion products of 17-4 PH martensitic stainless steel in the tropical marine environment

Journal of Materials Research and Technology
Deterioration of stainless steel is significantly influenced by the characteristics of corrosion products. Evolution of corrosion products of 17-4 PH martensitic stainless steel (17-4 PH MSS) in the tropical marine environment was systematically studied ...
Wenjie Zhang, Hongfei Yu, Yao Wang, Yange Yang, Bo Zhang, Xingqi Wang, Fuhui Wang   +6 more
doaj   +1 more source

Study of the TIG Welding Process of Thin-Walled Components Made of 17-4 PH Steel in the Aspect of Weld Distortion Distribution. [PDF]

Materials (Basel), 2023
Mróz M, Kucel B, Rąb P, Olszewska S.
europepmc   +1 more source