Results 121 to 130 of about 109,607,141 (279)

A kinetic model of the austenitization behavior of additively manufactured 17-4 PH martensitic stainless steel

open access: yesJournal of Materials Research and Technology
Austenitization is significant for understanding the microstructure and residual stress evolution in additive manufacturing of non-austenitic steels. However, the accurate modeling of austenite transformation of additively manufactured parts is rarely ...
Yi Liu   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Coordinatively and electronically unsaturated tetraruthenium clusters: Reversible triple CO addition to Ru-4(CO)(9)(mu-PPh2)[mu(4)-Ph2PCC(Ph)CC(Ph)]

open access: yes, 2011
[[abstract]]Two electronically unsaturated tetraruthenium clusters, Ru-4(CO)(9)(mu-PPh2)[mu(4)-Ph2PCC(Ph) CC(Ph)] (2) and Ru-4(CO)(10)(mu-PPh2)[mu(4)-Ph2PC(Ph)CCC(Ph)] (3), with spiked-triangular and open-chain structures have been synthesized via head ...
Delgado E;Chi Y;Wang WB;Hogarth G;Low PJ;Enright GD;Peng SM;Lee GH;Carty AJ
core  

Low strain hardening enables improved water droplet erosion performance through deep rolling

open access: yesJournal of Materials Research and Technology
The present work investigates the role of deep rolling surface treatment on the water droplet erosion behavior of 17–4 PH stainless steel. Standard heat treatments were first applied to samples of 17–4 PH stainless steel to achieve three states, solution
Rizwan Ahmed Shaik   +4 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Life at acidic pH imposes an increased energetic cost for a eukaryotic acidophile

open access: yes, 2005
Organisms growing in acidic environments, pH <3, would be expected to possess fundamentally different molecular structures and physiological controls in comparison with similar species restricted to neutral pH.
Jung, Sung-Kwon   +5 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Investigating the effects of hot isostatic pressing and proton irradiation on L-PBF stainless steels via nanoindentation across different strain rates

open access: yesResults in Engineering
The performance of additively manufactured (AM) 17-4 PH stainless steel in extreme environments, such as nuclear reactors, relies on its mechanical properties and microstructural stability.
Lutfun Nipa   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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