Results 131 to 140 of about 109,607,141 (279)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Effect of N Content on Ferrite Phase and Properties of  Maraging Stainless Steel 17-4 PH

Teshugang, 2019
The tested stainless steel 17-4PH (/% : 0.02 ~ 0. 03C, 0.40 ~ 0.50Si, 0.41 ~0. 60Mn, 0.018 ~ 0. 026P, 0. 001S, 15. 56 ~ 15.75Cr, 4. 31 ~ 4. 50Ni, 3. 21 ~ 3.40Cu, 0. 20 ~ 0.25Nb, 0. 013 〜0.
史咏鑫, 马胜斌, 才丽娟, 李青, 张欣杰, 冯文静   +5 more
doaj  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Fatigue Behavior of Selective Laser Melted 17-4 PH Stainless Steel [PDF]

, 2015
In this investigation, fully-reversed strain-controlled fatigue tests were conducted on Selective Laser Melted (SLM) 17-4 PH stainless steel (SS). Cylindrical 17-4 PH rods were fabricated vertically-upward using optimized process parameters to ensure a
Elwany, Alaa, Bian, Linkan, Mahmoudi, Mohamad, Shamsaei, Nima, Yadollahi, Aref, Thompson, Scott M.   +5 more
core  

Production and aging of highly porous 17-4 PH stainless steel

, 2011
This study describes production of highly porous 17-4 PH stainless steel for biomedical implant applications by space holder-sintering technique. 17-4 PH stainless steel powders were mixed with space holder and then compacted.
Ilven Mutlu, Enver Oktay, Mutlu, Ilven, Oktay, Enver   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Binder Jetting – Influence of shell printing on sintering densification and microstructure of 17-4 PH stainless steel

Materials & Design
The shell printing strategy was utilized for Binder Jetting of 17-4 PH stainless steel to investigate the impact of the binder on green density, sintering densification, phase transformations and microstructure gradients.
Kai Zissel, Gowtham Soundarapandiyan, Sophie Dubiez-Le Goff, Eduard Hryha   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Characterization of Conventionally and Additively Manufactured 17-4 PH Stainless Steel Hybrid Welded Joints

Metal additive manufacturing (AM) is a revolutionary technology that enables the on-demand production of intricate components directly from digital models.
Posey, Julianna Mariel
core   +1 more source