Results 161 to 170 of about 4,422 (206)

17-alpha hydroxyprogesterone caproate and risk for venous thromboembolism during pregnancy

The Journal of Maternal-Fetal & Neonatal Medicine, 2021
17-alpha hydroxyprogesterone caproate (17 P) is a progestin commonly used during pregnancy to reduce risk of recurrent preterm birth. History of thromboembolism is a contraindication to 17 P and the package insert for 17 P recommends discontinuation in the setting of an acute VTE event.
Meike, Schuster, Cande V, Ananth, Daniela, Gomez, Yongmei, Huang, Cynthia, Gyamfi-Bannerman, Jason D, Wright, Mary E, D'Alton, Alexander M, Friedman   +7 more
openaire   +2 more sources

Medical cost savings associated with 17 alpha-hydroxyprogesterone caproate

American Journal of Obstetrics and Gynecology, 2007
This study was undertaken to assess the impact of 17 alpha hydroxyprogesterone caproate treatment on future medical costs for expectant mothers with a prior spontaneous preterm birth.Data on the costs of preterm birth were combined with published data on the effectiveness of 17 alpha hydroxyprogesterone caproate to produce estimates of the effect of ...
Jennifer L, Bailit, Mark E, Votruba
openaire   +2 more sources

Preventing recurrent preterm birth with 125 mg of 17‐alpha‐hydroxyprogesterone caproate

Journal of Obstetrics and Gynaecology Research, 2021
AbstractAimThere is strong evidence that weekly intramuscular (IM) injections of 250 mg of 17‐alpha‐hydroxyprogesterone caproate (17‐OHPC) reduce the risk of recurrent preterm birth (PTB); however, whether a lower dose of 17‐OHPC could reduce the risk of recurrent PTB remains unclear.
Toma Fukuda, Hyo Kyozuka, Tsuyoshi Murata, Shun Yasuda, Akiko Yamaguchi, Keiya Fujimori   +5 more
openaire   +2 more sources

Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism

American Journal of Obstetrics and Gynecology, 2013
Plasma concentrations of 17-alpha-hydroxyprogesterone caproate (17-OHPC) vary substantially in pregnant patients who receive an identical dose. Endogenous steroid hormones may alter 17-OHPC metabolism, which contributes to this large variability.Pooled human liver microsomes were incubated with 17-OHPC alone or in combination with progesterone ...
Courtney D, Cuppett, Yang, Zhao, Steve, Caritis, Shimin, Zhang, Wenchen, Zhao, Raman, Venkataramanan   +5 more
openaire   +2 more sources

Progesterone, but not 17-alpha-hydroxyprogesterone caproate, inhibits human myometrial contractions

American Journal of Obstetrics and Gynecology, 2008
The aim was to determine whether progesterone (P4) or 17-alpha-hydroxyprogesterone caproate (17P) directly inhibit human uterine contractility in vitro and thereby clarify their mechanisms of action.Myometrial tissues were suspended in organ chambers and exposed for 2 to 20 hours to varying concentrations of P4 or 17P or solvent.
Nicole K, Ruddock, Shao-Qing, Shi, Sangeeta, Jain, Gradie, Moore, Gary D V, Hankins, Roberto, Romero, Robert E, Garfield   +6 more
openaire   +2 more sources

The 17-alpha hydroxyprogesterone chronicle

American Journal of Obstetrics and Gynecology, 2022
Jack Fitzsimmons, Wadia Mulla
openaire   +2 more sources

17 alpha-hydroxyprogesterone caproate, HIV, and preterm birth

The Lancet HIV, 2021
Robert, Ntozini, Andrew J, Prendergast
openaire   +2 more sources

A Trial of 17 Alpha-Hydroxyprogesterone Caproate to Prevent Prematurity in Twins

Obstetrical & Gynecological Survey, 2007
In singleton gestations, 17 alpha-hydroxyprogesterone caproate (17P) has been shown to reduce the rate of recurrent preterm birth. This study was undertaken to evaluate whether 17P would reduce the rate of preterm birth in twin gestations.We performed a randomized, double-blind, placebo-controlled trial in 14 centers. Healthy women with twin gestations
Dwight J, Rouse, Steve N, Caritis, Alan M, Peaceman, Anthony, Sciscione, Elizabeth A, Thom, Catherine Y, Spong, Michael, Varner, Fergal, Malone, Jay D, Iams, Brian M, Mercer, John, Thorp, Yoram, Sorokin, Marshall, Carpenter, Julie, Lo, Susan, Ramin, Margaret, Harper, Garland, Anderson   +16 more
openaire   +2 more sources

[Pharmacology of new gestagens: derivatives of 17-alpha-hydroxyprogesterone].

Farmakologiia i toksikologiia, 1989
The experimental data on the pharmacological activity of the modified analogs++ of 17 alpha-hydroxyprogesterone are presented. A high gestagenic activity was shown to be related to the presence of the methyl group in position 6, the double bond in position C6-C7, the hydroxyl and acetoxy groups in position 3.
openaire   +1 more source

Serum 17 alpha-hydroxyprogesterone in patients with gestational trophoblastic neoplasms.

Obstetrics and gynecology, 1977
Serum 17alpha-hydroxprogesterone (17-OHP), progesterone (P), and human chorionic gonadotropin (hCG) levels were measured by specific radioimmunoassay in 19 patients undergoing laparoscopy or laparotomy with either unevacuated molar pregnancy or nonmetastatic gestational trophoblastic neoplasms (GTN), in 10 normal pregnant patients at equivalent ...
R, Osathanondh, D P, Goldstein, D, Tulchinsky, A E, Finn   +3 more
openaire   +1 more source