Patient and Provider Perspectives on Acceptability, Access, and Adherence to 17-Alpha-Hydroxyprogesterone Caproate for Preterm Birth Prevention. [PDF]
Womens Health Rep (New Rochelle), 2021 Background: Preterm birth (PTB) is a pressing maternal and child health issue with long-standing racial inequities in outcomes and care provision. 17-Alpha-hydroxyprogesterone caproate (17OHPC) has been one of few clinical interventions for recurrent PTB
Garcia SM +4 more
europepmc +2 more sources
17-alpha hydroxyprogesterone caproate for the prevention of recurrent preterm birth among singleton pregnant women with a prior history of preterm birth: a systematic review and meta-analysis of six randomized controlled trials. [PDF]
Obstet Gynecol Sci, 2021 To perform a systematic review and meta-analysis of all randomized controlled trials (RCTs) that investigated the clinical benefits of 17-alpha hydroxyprogesterone caproate (17OHPC) in the prevention of recurrent preterm birth (PTB) among singleton ...
Baradwan S +10 more
europepmc +2 more sources
17-Alpha-Hydroxyprogesterone vs. Placebo for Preventing of Recurrent Preterm Birth: A Systematic Review and Meta-Analysis of Randomized Trials. [PDF]
Front Med (Lausanne), 2021 Background: Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality.Objective: To estimate the effect of 17-alpha-hydroxyprogesterone caproate (17-OHPC) compared to placebo in singleton gestations for reducing the risk of recurrent PTB
Almutairi AR, Aljohani HI, Al-Fadel NS.
europepmc +2 more sources
Smoking, 17 Alpha-Hydroxyprogesterone Caproate, and Preterm Birth. [PDF]
Am J Perinatol, 2016 Objective The objective of this study was to determine if maternal smoking modifies the effectiveness of 17 α-hydroxyprogesterone caproate (17OHP-C). Study Design Secondary analysis of the Maternal-Fetal Medicine Units Network trial of 17OHP-C. The prevalence of preterm birth (PTB) by smoking status and treatment group was compared by chi-squared ...
Heyborne KD, Allshouse AA.
europepmc +4 more sources
Effectiveness of 17-Alpha-Hydroxyprogesterone in the Prevention of Preterm Labour
Pakistan Armed Forces Medical Journal, 2023 Objective: To compare the effectiveness of 17-Alpha- Hydroxyprogesterone in preventing preterm labour. Study Design: Prospective longitudinal study. Place and Duration of Study: Department of Obstetrics and Gynecology, Combined Military Hospital, Sakardu Pakistan, from Jun to Dec 2019. Methodology: A total of 208 patients (104 in each
Uzma Urooj +3 more
openaire +3 more sources
Metabolism of 17-alpha-hydroxyprogesterone caproate by human placental mitochondria. [PDF]
Reprod Sci, 2012 Perfusion of 17-alpha-hydroxyprogesterone caproate (17HPC) via the maternal circuit of a dually perfused human placental lobule resulted in the extensive formation of 2 metabolites. On the other hand, human placental microsomes biotransformed 17HPC into 5 monohydroxylated metabolites, which did not correspond to those formed during perfusion.
Fokina VM +4 more
europepmc +4 more sources
Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention. [PDF]
Am J Obstet Gynecol, 2014 We hypothesized that genetic variation affects responsiveness to 17-alpha hydroxyprogesterone caproate (17P) for recurrent preterm birth prevention.Women of European ancestry with ≥1 spontaneous singleton preterm birth at
Manuck TA +7 more
europepmc +4 more sources
Progesterone Exposure in Pregnancy, Obstetric Stabilization, and Developmental Outcomes: A Focused Review of Direct and Indirect Pathways. [PDF]
Children (Basel)Background: Progesterone is an endogenous pregnancy hormone widely used in reproductive medicine and obstetrics. Its developmental relevance should be interpreted by distinguishing direct molecular plausibility from indirect obstetric effects, including ...
Dugalic S +3 more
europepmc +2 more sources
What Now? A Critical Evaluation of Over 20 Years of Clinical and Research Experience With 17-Alpha Hydroxyprogesterone Caproate for Recurrent Preterm Birth Prevention [PDF]
American Journal of Obstetrics & Gynecology MFM, 2023 Tracy A Manuck +2 more
exaly +2 more sources
Prenatal 17-Alpha-Hydroxyprogesterone Caproate Exposure in Twins and Childhood Outcomes: 14-Year Follow-Up of a Randomised Trial. [PDF]
BJOGABSTRACT Objective Long‐term child outcomes after intra‐uterine exposure to 17‐alpha‐hydroxyprogesterone caproate (17‐OHPC) versus placebo. Design Follow‐up of the AMPHIA randomised controlled trial assessing neonatal outcomes after weekly 17‐OHPC injections compared to placebo in multiple pregnancies. Setting Multicentre. Population or Sample Children
van Limburg Stirum EVJ +14 more
europepmc +2 more sources