Results 61 to 70 of about 8,864 (209)

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Figure 5 from Upregulation of Somatostatin Receptor Type 2 Improves ¹⁷⁷Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model

, 2023
Increased 177Lu-DOTATATE uptake induced by CI-994 treatment promotes tumor regression in QGP-1 xenograft model. A, Tumor volume (mm3) ± SEM from start to the end of pretreatment with CI-994 and injection of 30 MBq 177Lu-DOTATATE at day 0 (arrow).
Kwamena E. Baidoo (16815115), Rupali Sharma (16815109), James P. Madigan (16815121), Samira M. Sadowski (16815124), Bhargav Earla (16815112), Martha A. Zeiger (16815118), Freddy E. Escorcia (14941744)   +6 more
core   +1 more source

Relationship Between Best Tumor Shrinkage and Progression‐Free Survival and Overall Survival in Patients With Progressive Midgut Neuroendocrine Tumors Treated With [177Lu]Lu‐DOTA‐TATE: Ad Hoc Analysis of the Phase III NETTER‐1 Trial

Cancer Medicine
Background In many solid tumors, early tumor shrinkage predicts the durability of treatment response. It is unclear whether this is the case for neuroendocrine tumors treated with peptide receptor radionuclide therapy (PRRT).
Marianne Pavel, Martyn E. Caplin, Philippe Ruszniewski, Marianna Hertelendi, Eric P. Krenning, Jonathan R. Strosberg, the NETTER‐1 Study Group   +6 more
doaj   +1 more source

The role of [68 Ga]Ga-DOTATATE PET/CT in wild-type KIT/PDGFRA gastrointestinal stromal tumours (GIST)

EJNMMI Research, 2021
Background [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor radionuclide therapy with [177Lu]
Luigi Aloj, Olivier Giger, Iosif A. Mendichovszky, Ben G. Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A. Gallagher, Bala Attili, Mary McLean, Robin L. Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R. Maher, Ruth T. Casey   +16 more
doaj   +1 more source

Redefining the Role of Chemotherapy and Targeted Cytotoxic Delivery in Lung Neuroendocrine Tumors

Thoracic Cancer, Volume 17, Issue 16, August 2026.
Perioperative chemotherapy utility remains uncertain and lacks universal standardization. Platinum/etoposide shows suboptimal efficacy in lung NET (neuroendocrine tumors); oral alkylators (temozolomide) alone or in combination (e.g., with capecitabine), and cabozantinib offer promising disease control.
Alice Laffi, Giuseppe Lamberti, Anna La Salvia   +2 more
wiley   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Clinical Utility of 68Ga‐DOTATOC Positron Emission Tomography/Computed Tomography in Evaluating Metastatic Lesions of Clear Cell Renal Cell Carcinoma: A Case Report

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction 68Ga‐DOTATOC positron emission tomography/computed tomography (PET/CT) targets somatostatin receptors (SSTRs) and is an established molecular imaging modality for neuroendocrine tumors (NETs). Although SSTR expression has been reported in renal cell carcinoma (RCC), its clinical utility remains unclear. Case Presentation A 76‐year‐
Yuta Mine, Toru Sakatani, Sho Koyasu, Takashi Ogata, Yuki Teramoto, Akio Sakamoto, Takashi Mizowaki, Yuji Nakamoto, Takashi Kobayashi, Takayuki Goto   +9 more
wiley   +1 more source

Evaluation of the Interaction of Amino Acid Infusion on 177Lu-Dotatate Pharmacokinetics in Patients with Gastroenteropancreatic Neuroendocrine Tumors

, 2018
International audienceBackground and objective: 177Lu-Dotatate is a radio-labeled analog of somatostatin used in the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors.
Bauriaud-Mallet, Mathilde, Mathilde Bauriaud-Mallet, Etienne Chatelut, Frédéric Courbon, Bourgeois, Roxane, Dierickx, Lawrence, Roxane Bourgeois, Courbon, Frédéric, Alicja Puszkiel, Chatelut, Étienne, Lawrence Dierickx, Puszkiel, Alicja   +11 more
core   +1 more source

Preclinical Lutetium-177 Intracellular Dosimetry of Target Cancers in Radionuclide Therapy

Journal of Medical Physics
Purpose: This study investigates the preclinical dosimetry of Lutetium-177 in targeted radionuclide therapy for cancer treatment, focusing on the radiopharmaceutical [177Lu] Lu-DOTATATE.
Aleksandr S. Lunev, Kristina A. Petrosova, Kristina E. Ternovskaya, Alexandra E. Zakharkina, Aleksandra I. Nigmatulina   +4 more
doaj   +1 more source

Disturbing the Redox Balance Using Buthionine Sulfoximine Radiosensitized Somatostatin Receptor-2 Expressing Pre-Clinical Models to Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE

, 2023
Peptide receptor radionuclide therapy with 177Lu-DOTATATE improves the outcome of patients with somatostatin receptor (SSTR)-expressing neuroendocrine tumours.
Patrick Flamen, Delbart, Wendy, Marie Vercruyssen, Vercruyssen, Marie, Ghanem, Ghanem Elias, Basile Stamatopoulos, Zéna Wimana, Flamen, Patrick, Gwennaëlle Marin, Erwin Woff, Wimana, Zéna, Wendy Delbart, Pieter Demetter, Nicolas Sirtaine, Ghanem E. Ghanem, Sirtaine, Nicolas, De Wind, Roland, Ioannis Karfis, Demetter, Pieter, Roland de Wind, Stamatopoulos, Basile, Karfis, Ioannis, Marin, Gwennaëlle, Woff, Erwin   +23 more
core   +1 more source