Results 71 to 80 of about 140,614 (262)

The Role of 18F-FDG PET/CT Integrated Imaging in Distinguishing Malignant from Benign Pleural Effusion. [PDF]

PLoS ONE, 2016
The aim of our study was to evaluate the role of 18F-FDG PET/CT integrated imaging in differentiating malignant from benign pleural effusion.A total of 176 patients with pleural effusion who underwent 18F-FDG PET/CT examination to differentiate ...
Yajuan Sun, Hongjuan Yu, Jingquan Ma, Peiou Lu   +3 more
doaj   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Synthesis and Biological Evaluation of 3-O-(2-18F-fluoroethyl)-L-DOPA as A Potential PET Agent for Tumor Imaging

Journal of Isotopes, 2020
As a complementary category to 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG), radiolabeled amino acids have been successfully employed for tumor imaging.
MA Jingxin1;WU Zhou2;JIANG Shende2;WANG Hongliang1,3;WU Zhifang1,3
doaj   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

DUAL-TRACER PET/CT IMAGING IN HEPATOCELLULAR CARCINOMA: COMPARING THE PERFORMANCE OF 18F-FDG AND 18F-PSMA

Hematology, Transfusion and Cell Therapy
Introduction/Justification: Hepatocellular carcinoma (HCC) is a prevalent malignancy with rising incidence in Western countries, often diagnosed at advanced stages. Early detection and accurate assessment of tumor extent are crucial for optimal treatment
Giulia Picciola Bordoni, Maria Emilia Seren Takahashi, Fabíola F. Zarpelão, Najua A. A Silveira, Victor C.C.R. Heringer, Simone Kuba, TobarNatália, Sergio Q Brunetto, Carmino A Souza, José Barreto Carvalheira, Celso Dario Ramos   +10 more
doaj   +1 more source

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

EJNMMI Research, 2019
Purpose We have previously developed the caspase-based radiotracer, 18F-ICMT-11, for PET imaging to monitor treatment response. We further validated 18F-ICMT-11 specificity in a murine melanoma death-switch tumour model with conditional activation of ...
Vessela Vassileva, Stephen M. Stribbling, Chris Barnes, Laurence Carroll, Marta Braga, Joel Abrahams, Kathrin Heinzmann, Caroline Haegeman, Marion MacFarlane, Kathryn L. Simpson, Caroline Dive, Jamie Honeychurch, Timothy M. Illidge, Eric O. Aboagye   +13 more
doaj   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

An intra-individual comparison of MRI, [18F]-FET and [18F]-FLT PET in patients with high-grade gliomas.

PLoS ONE, 2014
ObjectivesIntra-individual spatial overlap analysis of tumor volumes assessed by MRI, the amino acid PET tracer [18F]-FET and the nucleoside PET tracer [18F]-FLT in high-grade gliomas (HGG).MethodsMRI, [18F]-FET and [18F]-FLT PET data sets were ...
Martha Nowosielski, Matthew D DiFranco, Daniel Putzer, Marcel Seiz, Wolfgang Recheis, Andreas H Jacobs, Günther Stockhammer, Markus Hutterer   +7 more
doaj   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Assessment of glucose metabolism and cellular proliferation in multiple myeloma: a first report on combined 18F-FDG and 18F-FLT PET/CT imaging

EJNMMI Research, 2018
Background Despite the significant upgrading in recent years of the role of 18F-FDG PET/CT in multiple myeloma (MM) diagnostics, there is a still unmet need for myeloma-specific radiotracers. 3′-Deoxy-3′-[18F]fluorothymidine (18F-FLT) is the most studied
C. Sachpekidis, H. Goldschmidt, K. Kopka, A. Kopp-Schneider, A. Dimitrakopoulou-Strauss   +4 more
doaj   +1 more source