Results 81 to 90 of about 140,614 (262)

Fitting parameters of 18F-FDG, 18F-FET and 18F-FCho in GB and RN.

, 2016
Fitting parameters of 18F-FDG, 18F-FET and 18F-FCho in GB and RN.
Caroline Van den Broecke (3079581), Filip De Vos (526780), Ingeborg Goethals (849158), Tom Boterberg (3079578), Karel Deblaere (3079569), Kelly Lybaert (3079566), Lieselotte Moerman (2356681), Christian Vanhove (772792), Julie Bolcaen (3079572), Benedicte Descamps (772793), Jean-Pierre Kalala (3079575)   +10 more
core   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Radiosynthesis and use of [18F]F2 derivatives [18F]Selectfluor bis(triflate) and [18F]ClF [PDF]

, 2014
Positroniemissiotomografia (PET) on kajoamaton kuvantamismenetelmä, jolla voidaan tutkia biologisia ja farmakologisia prosesseja elävissä ihmisissä ja eläimissä. PET käyttää biologisesti aktiivisia yhdisteitä, joihin on liitetty lyhytikäinen positroni (β+
Kirjavainen, Anna
core  

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis [PDF]

, 2012
There is growing evidence of activated microglia and inflammatory processes in the cerebral cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain
Philippe Corcia, Tauber, Clovis, Yann Venel, Nicolas Arlicot, Corcia, Philippe, Hommet, Caroline, Praline, Julien, Kassiou, Michael, Johnnie Vercoullie, Arlicot, Nicolas, Guilloteau, Denis, Catherine Roussel, Ribeiro, Maria-Joao, Caroline Hommet, Prunier, Caroline, Roussel, Catherine, Baulieu, Jean-Louis, Clovis Tauber, Guillaume Nicolas, Jean-Louis Baulieu, Julien Praline, Venel, Yann, Nicolas, Guillaume, Mickael Kassiou, Vercouillie, Johnny, Cottier, Jean-Philippe, Maria-Joao Ribeiro, Caroline Prunier, Jean-Philippe Cottier, Denis Guilloteau, Hommet Caroline, Corcia Philippe, Venel Yann, Vercoullie Johnnie, Arlicot Nicolas, Praline Julien, Guilloteau Denis, Kassiou Mickael, Prunier Caroline, Nicolas Guillaume, Ribeiro Maria-Joao, Tauber Clovis, Cottier Jean-Philippe, Roussel Catherine, Baulieu Jean-Louis   +44 more
core   +2 more sources

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate.

, 2022
Background/Aims: [18F]Fluoroalkyl groups are essential labeling units because they are considered as surrogates for [11C]methyl moieties, and are coupled to the same functional units as the [11C]methyl group.
Wakana, Mori, 1054109, Masanao, Ogawa, 1054106, 1054105, 1054108, 1054107, 1054102, 1054101, 1054104, 1054103, 1054100, Kazunori, Kawamura, Nobuki, Nengaki, Zhang, Ming-Rong, Ohkubo, Takayuki, Hiroki, Hashimoto, 1054112, Masayuki, Fujinaga, 1054098, 1054097, Kurihara, Yusuke, 1054111, 1054099, 1054110, 1054094, 1054093, 1054096, 1054095, Kaito, Tsukagoe   +29 more
core  

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes

, 2021
18F-fluorination using aluminum-fluoride ([18F]AlF) chelate technique has been reported to give a low-to-moderate radiochemical yield, between 5 and 20%. Therefore, the work described here outlines the optimum 18F-fluorination condition for the formation
Abdul Razak, Hairil Rashmizal, Hassan, Hishar, Othman, Muhammad Faiz   +2 more
core   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

A Practical Method for the Preparation of 18F-Labeled Aromatic Amino Acids from Nucleophilic [18F]Fluoride and Stannyl Precursors for Electrophilic Radiohalogenation

Molecules, 2017
In a recent contribution of Scott et al., the substrate scope of Cu-mediated nucleophilic radiofluorination with [18F]KF for the preparation of 18F-labeled arenes was extended to aryl- and vinylstannanes.
Fadi Zarrad, Boris D. Zlatopolskiy, Philipp Krapf, Johannes Zischler, Bernd Neumaier   +4 more
doaj   +1 more source