Results 131 to 140 of about 158,818 (264)
PLoS ONEMolecular methods in clinical and research applications frequently encounter complex mixtures of human and microbial DNA, sometimes alongside environmental or reagent contaminants.
Guohong Huang +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Soil fungal community associated with peat in Sarawak identified using 18S rDNA marker
, 2016 Fungi are principal decomposing microorganisms in acidic environment of peatlands. A useful tool for molecular screening of soil fungal communities using the 18S rDNA primer has been proven capable of identifying a broad range of fungi species within ...
Bakeri, S.A. +4 more
core
, 2012 DNA sequence alignment of the 18S rRNA gene in Nexus ...
Ilan, Micha +13 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
, 2017 B-18s flying over Hawaii in formationhttps://nsuworks.nova.edu/nasfl/1283/thumbnail ...
Courtesy of the Naval Air Station Fort Lauderdale Museum
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Miscleaved 18S rRNA are rare in vivo.
(A, B) 3′-RACE-sequencing of 18S rRNA extracted from 40S subunits purified from Gal::Pno1;Gal::Dim1 cells grown in glucose to deplete endogenous Pno1 and Dim1 and supplemented with plasmids encoding Pno1 and Dim1-E85A, an inactive mutant that prevents ...
Elise S. Brunk (18447335) +3 more
core +1 more source