Results 121 to 130 of about 134,822 (364)
Advanced Healthcare Materials, EarlyView.AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan +3 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex +4 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Molecular Characterization of a Non–Babesia divergens Organism Causing Zoonotic Babesiosis in Europe
Emerging Infectious Diseases, 2003 In Europe, most reported human cases of babesiosis have been attributed, without strong molecular evidence, to infection with the bovine parasite Babesia divergens.
Barbara L. Herwaldt +13 more
doaj +1 more source
Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]
, 2012 Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter +5 more
core +1 more source
Advanced Healthcare Materials, EarlyView.A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi +10 more
wiley +1 more source
The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]
, 2007 CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris +6 more
core +1 more source
Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Advanced Healthcare Materials, EarlyView.Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang +6 more
wiley +1 more source
HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]
, 2013 The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem +68 more
core +1 more source
Advanced Materials, EarlyView.Integration of computational and experimental approaches for deciphering the underlying mechanism of biomolecular condensates and potential biomaterials design (Created in Biorender. Raza, Z. (2025) https://BioRender.com/irgmeqi). Abstract Biomolecular condensates, a ubiquitous class of biomaterials found in living cells, have been shown to be ...
Qiang Zhu +10 more
wiley +1 more source