High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1
Advanced Science, EarlyView.This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng +11 more
wiley +1 more source
Advanced Science, EarlyView.A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma +13 more
wiley +1 more source
CoFold: thermodynamic RNA structure prediction with a kinetic twist [PDF]
arXiv, 2012 Existing state-of-the-art methods that take a single RNA sequence and predict the corresponding RNA secondary-structure are thermodynamic methods. These predict the most stable RNA structure, but do not consider the process of structure formation. We have by now ample experimental and theoretical evidence, however, that sequences in vivo fold while ...
arxiv
Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer
Cell Reports, 2020 Summary: The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA).
Artem Babaian +10 more
doaj
18S ribosomal DNA-based PCR test for avian and mammalian DNA identification in meat products
Veterinary and Animal Science, 2022 This work has aimed to create a PCR test to identify avian and mammalian DNA in meat products. The test is based on phylogenetic analysis of 18S ribosomal RNA (rRNA) of four major groups of Tetrapod: Amphibia, Reptilia, Mammalia, and Aves.
Irina M. Zyrianova, Oleg G. Zaripov
doaj
Utilization of 18s ribosomal RNA LAMP for detecting Plasmodium falciparum in microscopy and rapid diagnostic test negative patients. [PDF]
PLoS One, 2022 Aninagyei E +7 more
europepmc +1 more source
MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue
Advanced Science, EarlyView.This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao +17 more
wiley +1 more source
Does high sugar intake really alter the oral microbiota?: A systematic review
Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1376-1390, December 2022., 2022 Abstract Objectives Diet is one of the main factors influencing the diversity and interactions of the oral microbiota. The purpose of this study is to determine the impact of sugar intake on the microbial diversity and bacteria that predominate under these conditions.
María del Pilar Angarita‐Díaz +3 more
wiley +1 more source
Specific interaction of one subunit of eukaryotic initiation factor eIF-3 with 18S ribosomal RNA within the binary complex, eIF-3.small ribosomal subunit, as shown by cross-linking experiments [PDF]
, 1982 Odd Nygârd, Peter Westermann
openalex +1 more source
A Sequential Release Micro‐nano System for Colitis Therapy via Gut Microbiota and Immune Regulation
Angewandte Chemie, EarlyView.The micro‐nano system achieves the sequential release of drugs in response to gut microbiota and reactive oxygen species (ROS). Inulin prebiotics restore gut microbiota balance. Selenium compounds scavenge ROS and promote macrophage polarization, while 3‐oxolithocholic acid suppresses TH17‐cell differentiation. As a multifactorial therapeutic approach,
Dongdong Zhu +9 more
wiley +2 more sources