The 18S rRNA m6A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation
EMBO Reports, 2020 RNA modifications represent a novel layer of regulation of gene expression. Functional experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays critical roles in cell fate determination and development.
Ming Xing +12 more
semanticscholar +1 more source
Integrative description of Macrobiotus canaricus sp. nov. with notes on M. recens (Eutardigrada : Macrobiotidae) [PDF]
, 2018 In this paper we describe Macrobiotus canaricus sp. nov., a new tardigrade species of the Macrobiotus hufelandi group from the Canary Islands. Moreover, with the use of DNA sequencing, we confirm that Macrobiotus recens Cuénot, 1932 represents the ...
Krzywański, Łukasz +2 more
core +1 more source
18S rRNA: A Tale of the Tail [PDF]
Journal of Molecular Biology, 2011 More than 40 years ago, the Nomura group seduced the ribosome community with the breath-takingly simple reconstitution of the 30S ribosomal subunit from its component RNA and proteins (1). However, as with many seductions, the morning-after reality is sobering.
openaire +2 more sources
Detection of Plasmodium simium gametocytes in non-human primates from the Brazilian Atlantic Forest
Malaria Journal, 2023 Background Plasmodium species of non-human primates (NHP) are of great interest because they can naturally infect humans. Plasmodium simium, a parasite restricted to the Brazilian Atlantic Forest, was recently shown to cause a zoonotic outbreak in the ...
Lara Cotta Amaral +12 more
doaj +1 more source
Detection and identification of Leishmania species within naturally infected sand flies in the Andean areas of Ecuador by a polymerase chain reaction [PDF]
, 2005 The surveillance of prevalent Leishmania and sand fly species in endemic areas is important for prediction of the risk and expansion of leishmaniasis. In this study, we developed a polymerase chain reaction (PCR)-based method for detection of Leishmania ...
Barroso, Paola Andrea +11 more
core +1 more source
Novel Cryptosporidium genotype in wild Australian mice (Mus domesticus) [PDF]
, 2007 A total of 250 mouse fecal specimens collected from crop farms in Queensland, Australia, were screened for the presence of Cryptosporidium spp. using PCR.
Boxell, A. +4 more
core +3 more sources
An RNA Conformational Switch Regulates Pre-18S rRNA Cleavage [PDF]
Journal of Molecular Biology, 2011 To produce mature ribosomal RNAs (rRNAs), polycistronic rRNA transcripts are cleaved in an ordered series of events. We have uncovered the molecular basis for the ordering of two essential cleavage steps at the 3'-end of 18S rRNA. Using in vitro and in vivo structure probing, RNA binding and cleavage experiments, and yeast genetics, we demonstrate that
Allison C, Lamanna, Katrin, Karbstein
openaire +2 more sources
Maturation of the 90S pre-ribosome requires Mrd1 dependent U3 snoRNA and 35S pre-rRNA structural rearrangements [PDF]
, 2018 In eukaryotes, ribosome biogenesis requires folding and assembly of the precursor rRNA (pre-rRNA) with a large number of proteins and snoRNPs into huge RNA-protein complexes. In spite of intense genetic, biochemical and high-resolution cryo-EM studies in
Barandun +65 more
core +1 more source
Genes and Diseases, 2020 Ribosome RNA (rRNA) accounts for more than 80% of the cell's total RNA, while the physiological functions of rRNA modifications are poorly understood.
Lu Wang +15 more
semanticscholar +1 more source
Electrochemical detection of the toxic dinoflagellate Alexandrium ostenfeldii with a DNA-biosensor [PDF]
, 2005 The steady rise of observations of harmful or toxic algal blooms throughout the world in the past decades constitute a menace for coastal ecosystems and human interests.
Huljic, S. +3 more
core +1 more source