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In vitro evaluation of the effects of anti‐fungals, benzodiazepines and non‐steroidal anti‐inflammatory drugs on the glucuronidation of 19‐norandrosterone: implications on doping control analysis

Drug Testing and Analysis, 2015
We have studied whether the phase II metabolism of 19‐norandrosterone, the most representative metabolite of 19‐nortestosterone (nandrolone), can be altered in the presence of other drugs that are not presently included on the Prohibited List of the World Anti‐Doping Agency.
PALERMO, AMELIA   +5 more
openaire   +4 more sources

Determination of 19-norandrosterone in human urine by isotope dilution gas chromatography-high resolution mass spectrometry

Accreditation and Quality Assurance, 2007
An accurate and precise method for the determination of total 19-norandrosterone (19-NA), a major metabolite of nandrolone, in human urine was developed based on isotope dilution gas chromatography-high resolution mass spectrometry (ID GC-HRMS). The 19-NA glucuronide, together with deuterated 19-NA (d4-19-NA) (as the internal standard, IS), was ...
Wing-Chi Cheng   +4 more
openaire   +2 more sources

Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. I. Mass spectrometric detection and quantification of 19-norandrosterone and 19-noretiocholanolone in human urine

Rapid Communications in Mass Spectrometry, 2000
For the first time in the field of steroid residues in humans, demonstration of 19-norandrosterone (19-NA: 3alpha-hydroxy-5alpha-estran-17-one) and 19-noretiocholanolone (19-NE: 3alpha-hydroxy-5beta-estran-17-one) excretion in urine subsequent to boar consumption is reported.
Le Bizec, Bruno   +6 more
openaire   +5 more sources

Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. II. Identification and quantification of 19‐norsteroids responsible for 19‐norandrosterone and 19‐noretiocholanolone excretion in human urine

Rapid Communications in Mass Spectrometry, 2001
Abstract In previous work (Le Bizec et al ., Rapid Commun. Mass Spectrom . 2000; 14: 1058), it was demonstrated that a boar meal intake could lead to possible false accusations of abuse of 17β‐nortestosterone in antidoping control. The
K, De Wasch   +4 more
openaire   +3 more sources

A high-accuracy method of analysis of 19-norandrosterone in human urine as utilised for the international laboratory intercomparison CCQM-P68

Accreditation and Quality Assurance, 2007
A high-accuracy exact-matching isotope dilution mass spectrometry (IDMS) method for 19-norandrosterone (19-NA) in human urine was developed at NMIA for the certification of a freeze-dried human urine reference material (CRM NMIA MX002). The method utilised GC/HRMS analysis following hydrolysis, solvent extraction, HPLC fractionation and derivatisation.
Lindsey G. Mackay   +7 more
openaire   +2 more sources

Determination of 19-norandrosterone in CCQM-P68. NIST results using an isotope dilution liquid chromatography/tandem mass spectrometry method

Accreditation and Quality Assurance, 2007
The US National Institute of Standards and Technology (NIST) participated in an international interlaboratory study under the auspices of the Consultative Committee for Amount of Substance (CCQM) for the determination of 19-norandrosterone (19-NA) in urine, the principal metabolite of nandrolone and certain other synthetic testosterone substitutes ...
Susan S. -C. Tai   +2 more
openaire   +2 more sources

An international intercomparison for 19-norandrosterone in human urine: the Comité Consultatif pour la Quantité de Matière (CCQM) Pilot Study CCQM-P68

Accreditation and Quality Assurance, 2007
Under the auspices of the Comite Consultatif pour la Quantite de Matiere (CCQM) a laboratory intercomparison, CCQM-P68, was co-ordinated by the National Measurement Institute of Australia (NMIA) in 2005 involving the analysis of the steroid 19-norandrosterone (19-NA) in human urine.
Lindsey G. Mackay   +7 more
openaire   +2 more sources

Development and Evaluation of a Candidate Reference Measurement Procedure for the Determination of 19-Norandrosterone in Human Urine Using Isotope-Dilution Liquid Chromatography/Tandem Mass Spectrometry

Analytical Chemistry, 2006
19-Norandrosterone (19-NA) is the major metabolite of the steroid nandrolone, one of the most commonly abused anabolic androgenic agents. 19-NA exists mainly as the glucuronide form in human urine. A candidate reference measurement procedure for 19-NA in urine involving isotope dilution coupled with liquid chromatography/tandem mass spectrometry (LC/MS/
Susan S-C, Tai   +3 more
openaire   +3 more sources

Analysis of 19-norandrosterone in human urine by gas chromatography–isotope-dilution mass spectrometry: method adopted by LGC for participation in the Comité Consultatif pour la Quantité de Matière (CCQM) Pilot Study P68

Accreditation and Quality Assurance, 2007
The method used at LGC for analysis of “total” 19-norandrosterone (19-norandrosterone glucuronide plus “free” 19-norandrosterone) in urine for the Comite Consultatif pour la Quantite de Matiere Pilot Study (CCQM-P68) is described. The analytical method used was a modified version of the method developed at the National Measurement Institute of ...
Chris Mussell   +3 more
openaire   +2 more sources

Method validation for the detection of the anabolic–androgenic steroids methenolone and 19-norandrosterone in wastewater and application to real wastewater samples

Environmental Monitoring and Assessment
Berfin Sude Ertas   +5 more
openaire   +2 more sources

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