Results 21 to 30 of about 340,819 (247)

Venezuela 1936 – 2021:

Revista Brasileira de História & Ciências Sociais, 2021
Revisar la movilidad internacional de Venezuela desde 1936 hasta 2021 es un desafío y una tarea compleja. Durante ese tiempo, ocurrieron importantes eventos políticos, económicos y sociales, una época en la que los extranjeros ayudaron a construir un ...
Emilio Osorio Alvarez, Mauricio Phélan, Carlos Viso   +2 more
doaj   +1 more source

Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population‐Based Study and Gut Microbiota Analysis

Advanced Science, EarlyView.
Frequent sweetened beverage consumption is associated with accelerated biological aging in a large Chinese population. Five gut microbial genera are consistently enriched in both frequent sweetened beverage consumers and individuals with accelerated aging and show significant mediating effects, suggesting a potential microbiota‐related pathway linking ...
Yuwei Shi, Xinmei Li, Yufan Hao, Qiaoyu Wu, Yuji Yu, Siyu Li, Nuo Xu, Yi‐Hsuan Wu, Eunhye Lee, Chi Chang, Emily Hu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Shankuan Zhu   +14 more
wiley   +1 more source

Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation

Journal for ImmunoTherapy of Cancer, 2017
Background Human γδ T cells expressing Vγ2Vδ2 T cell receptors monitor foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis to mediate immunity to microbes and tumors.
Hong Wang, Mohanad H. Nada, Grefachew Workalemahu, Yoshimasa Tanaka, Craig T. Morita   +4 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Phylogenomic insights into the genus Tulipa (Liliaceae): Taxonomy, evolution, and biogeography

American Journal of Botany, EarlyView.
Abstract Premise Tulips are one of the best‐known geophytes, but their taxonomy remains convoluted and their evolutionary history poorly understood. Here, we used plastid genomes to identify some issues with current classification, understand the diversification history of the genus, and identify potential species linked to historical cultivation ...
Brett Wilson, Maarten J. M. Christenhusz, Nathanael Walker‐Hale, Natalya Beshko, Mariyo Boboev, Colin Clubbe, Davron Dekhkonov, Aibek Dolotbakov, Mehmet Firat, Thomas Freeth, Sjaak de Groot, Avni Hajdari, Georgy A. Lazkov, Ormon Sultangaziev, Komiljon S. Tojibaev, Ben J. M. Zonneveld, Kaiyrkul T. Shalpykov, Samuel F. Brockington   +17 more
wiley   +1 more source

Analyses of the peripheral immunome following multiple administrations of avelumab, a human IgG1 anti-PD-L1 monoclonal antibody

Journal for ImmunoTherapy of Cancer, 2017
Background Multiple anti-PD-L1/PD-1 checkpoint monoclonal antibodies (MAb) have shown clear evidence of clinical benefit. All except one have been designed or engineered to omit the possibility to mediate antibody-dependent cell-mediated cytotoxicity ...
Italia Grenga, Caroline Jochems, Massimo Fantini, James L. Gulley, Christopher R. Heery, Renee N. Donahue, Ravi A. Madan, Jeffrey Schlom, Lauren M. Lepone   +8 more
doaj   +1 more source

Spectroscopic and In Silico Determination of the Structural and Antioxidant Properties of Essential Oils From Lavandula Species Cultivated in the Silivri Region of Istanbul

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Plants are important sources of bioactive compounds that contribute to nutrition, health maintenance, and disease prevention. In this study, the chemical composition and antioxidant potential of essential oils obtained from Lavandula angustifolia “Sevtopolis” and Lavandula × intermedia cultivated in the Silivri region of Istanbul were ...
Bilge Bicak, Beray Kizilkaya, Serda Kecel Gunduz, Aliye Demet Demirag, Sabriye Percin Ozkorucuklu   +4 more
wiley   +1 more source

Ondina Valla, une « championne du fascisme » aux Jeux olympiques de Berlin (1936)

Genre & Histoire
At the 1936 Olympic Games in Berlin, at the age of 20, Trebisonda Valla, nicknamed Ondina, became the first Italian woman to win an Olympic gold medal. This personal endeavor quickly became an unwilling hostage of the Fascist dictatorship which declared ...
Suzy Toson
doaj   +1 more source

Origin, evolution and biogeographic dynamics of the European rabbit (Oryctolagus cuniculus) in Southwestern Europe

The Anatomical Record, EarlyView.
Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley   +1 more source

FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer

Journal for ImmunoTherapy of Cancer, 2017
Immunotherapy has had remarkable success in the treatment of some cancer types. However, pancreatic cancer has remained largely refractory to immunotherapy, including immune checkpoint inhibitors.
Stefan N. Symeonides, Stephen M. Anderton, Alan Serrels   +2 more
doaj   +1 more source