Results 211 to 220 of about 1,276,554 (318)

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang   +12 more
wiley   +1 more source

Design Space Assessment of Virus Inactivation in Plasma‐Derived Matrices Establishes a Single Detergent Alternative to TX‐100‐Containing Mixes

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The detergent Triton X‐100 (TX‐100) is a typical component of solvent/detergent (S/D) mixes applied for virus inactivation steps of biomanufacturing processes, yet environmentally unfavorable properties have led to restrictions on its use. Deviron 13‐S9 has recently been described as an eco‐friendly TX‐100 alternative, with powerful virus ...
Johanna Kindermann   +3 more
wiley   +1 more source

Real‐Time Biomass Estimation in High‐Density Yeast Fermentations Using Soft Sensor Modeling

open access: yesBiotechnology and Bioengineering, EarlyView.
Accurate biomass measurements, both offline and online, are essential to improve prediction and control in yeast fermentation. This study develops regression‐based predictive models to correlate offline measurements (Dry Cell Weight and OD600 from a spectrophotometer) with online OD860 probe signals to provide accurate real‐time biomass estimations and
Ana G. Del Hierro   +3 more
wiley   +1 more source

Density Estimates of Endangered Endemic Rodents Suggest Broader Impacts of Invasive Burmese Pythons Following a Category 4 Hurricane in the Florida Keys

open access: yesBiological Diversity, EarlyView.
Density estimates of two endangered rodent subspecies, endemic to Key Largo, Florida, USA. These findings illustrate the contrasting dynamics of two native species associated with the prevalence of invasive Burmese pythons and global change. The woodrats' decline emphasizes its potential risk of extinction as global change continues to impact island ...
Shauna M. Sayers   +5 more
wiley   +1 more source

Tiedotustutkimus vsk 1983

open access: yesMedia & Viestintä, 1984
Toimitus Media & viestintä
doaj  

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

open access: yesBiological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon   +5 more
wiley   +1 more source

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