Results 91 to 100 of about 763 (144)

2,4,5-Trichlorophenoxyacetic acid inhibits apoptosis in PC12 cells

Life Sciences, 2001
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) is an endocrine disrupter that exerts cytotoxic effects on organisms. In this study, the influence of 2,4,5-T at low concentrations on apoptosis in PC 12 cells was investigated. Although no apoptotic features were observed in PC12 cells treated with 2,4,5-T, it inhibited the DNA fragmentation induced by serum
Toshiyuki Hosokawa, Masaaki Kurasaki
exaly   +3 more sources

Dechlorination of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid in soil

Science of the Total Environment, 1998
The potential for dechlorinating 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) in selected soils with a mixed culture showing stable dechlorinating activity was investigated. Intermediate 2,4,5-T dechlorination products were identified as 2,5-D and 3-CP, while the intermediate 2,4-D dechlorination product was ...
B.-V Chang, J.-Y Liu, S.-Y Yuan
exaly   +2 more sources

Distribution of 2,4,5-trichlorophenoxyacetic acid in the mouse fetus

Toxicology Letters, 1977
Abstract The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) readily crosses the placenta in the mouse on gestational day 13. Concentrations of 2,4,5-T in maternal tissues and fetuses were obvious at 30 min, highest at 8 h, diminished by 24 h and almost entirely eliminated by 48 h.
K.D. Courtney, M.T. Ebron, A.W. Tucker
exaly   +2 more sources

Teratogenic studies on 2,4,5-trichlorophenoxyacetic acid in the rat and rabbit

Food and Cosmetics Toxicology, 1971
Abstract Groups of Sprague-Dawley-derived rats received daily oral doses of 1, 3, 6, 12 or 24 mg 2,4,5-T/kg on days 6–15 of gestation. Groups of New Zealand White rabbits received daily oral doses of 10, 20 or 40 mg 2,4,5-T/kg on days 6–18 of gestation.
J L, Emerson, D J, Thompson, R J, Strebing, C G, Gerbig, V B, Robinson   +4 more
openaire   +2 more sources

The metabolism and distribution of 2,4,5-trichlorophenoxyacetic acid in female rats

Toxicology and Applied Pharmacology, 1973
Abstract [1-14C]-2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) was fed to pregnant and non-pregnant female rats at various dosages, and expired air, urine, feces, internal organs and tissues were analyzed for radioactivity. During the first 24 hr, 75 ± 7% of the radioactivity was excreted in the urine and 8.2 ± 4.6% in the feces.
S C, Fang, E, Fallin, M L, Montgomery, V H, Freed   +3 more
openaire   +2 more sources

SERS Chemical Enhancement of 2,4,5-Trichlorophenoxyacetic Acid Adsorbed on Silver Substrate

The Journal of Physical Chemistry A, 2021
Surface-enhanced Raman spectroscopy (SERS) was employed to gain an understanding of the chemical enhancement mechanism of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), an Agent Orange, adsorbed on a silver substrate surface. Experimental measurements were performed using a micro-Raman spectrophotometer with an excitation wavelength of 532 nm and ...
Duy Quang Dao, Thi Chinh Ngo, Thi Thuy Huong Le, Quang Thang Trinh, Thi Le Anh Nguyen, Bui The Huy, Nguyen Ngoc Tri, Nguyen Tien Trung, Minh Tho Nguyen   +8 more
openaire   +2 more sources

Microbial Biodegradation of 2,4,5-Trichlorophenoxyacetic Acid and Chlorophenols

1984
We have succeeded in isolating a pure culture of Pseudomonas cepacia, AC1100, from a chemostat enrichment culture experiment that is capable of growing on 2,4,5-trichlorophenoxyacetic acid as its sole source of carbon and energy. AC1100 is not only capable of degrading 2,4,5-T but is also able to completely or partially dehalogenate a wide variety of ...
J S, Karns, J J, Kilbane, D K, Chatterjee, A M, Chakrabarty   +3 more
openaire   +2 more sources

Biliary excretion of 2,4,5-trichlorophenoxyacetic acid in the rat

Toxicology Letters, 1982
Urethane-anesthetized, male Sprague-Dawley rats were administered 25 mg/kg 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) intravenously. 6 h after administration, 15.7% of the dose was recovered in the bile. Reversed-phase high-performance liquid chromatography (HPLC) analysis of bile indicated that more than 85% of compound excreted in bile was unchanged
openaire   +2 more sources

Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats

Experientia, 1983
Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.
M A, Crampton, L J, Rogers
openaire   +2 more sources

A Mortality Analysis of Employees Engaged in the Manufacture of 2,4,5-Trichlorophenoxyacetic Acid

Journal of Occupational and Environmental Medicine, 1980
There have been few published reports regarding surveillance of individuals occupationally exposed to 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). The present study examined the mortality experience of 204 persons exposed to 2,4,5-T during its manufacture from 1950 to 1971.
M G, Ott, B B, Holder, R D, Olson
openaire   +2 more sources