Enhanced kinetic stability of [Pd2L4](4+) cages through ligand substitution
, 2016 There is considerable interest in exploiting metallosupramolecular cages as drug delivery vectors. Recently, we developed a [Pd2L4]4+ cage capable of binding two molecules of cisplatin.
Crowley, JD +4 more
core +2 more sources
Molecular imprinting for neurology: Materials, applications, and limitations
Ibrain, Volume 12, Issue 1, Page 3-37, Spring 2026.Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma +3 more
wiley +1 more source
Equine Veterinary Journal, Volume 58, Issue 2, Page 333-347, March 2026.Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik +2 more
wiley +1 more source
A Novel Oligosaccharide on Bovine Peripheral Myelin Glycoprotein P0 [PDF]
, 2003 Sulfated oligosaccharides have found in glycoproteins in myelin in the PNS, such as P0 and PASII/PMP22. These glycoproteins are involved in the interaction of cell membranes and play important roles in the formation and maintenance of myelin sheaths ...
北村 邦男, 野村 正彦, 閻 剣虹
core
Exploring the use of dalfampridine (4‐aminopyridine) for treatment of ataxia in cerebellar stroke
PM&R, EarlyView.
Arjun Kotwal +4 more
wiley +1 more source
Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery
ChemMedChem, Volume 21, Issue 4, 25 February 2026.Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley +1 more source
Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R. [PDF]
J Enzyme Inhib Med Chem, 2023 Liu S +12 more
europepmc +1 more source
Conversion of Vernonia galamensis oil to pyridinyl-vernolamides and their antimicrobial activities
Bulletin of the Chemical Society of Ethiopia, 2007 Vernonia oil obtained by Soxhlet extraction from the seeds of Vernonia galamensis ssp. nairobensis was reacted with 2-aminopyridine, 2-(aminomethyl)pyridine and 2-(aminoethyl)pyridine using a 1:3 mole ratio of vernonia oil to amine at varied temperatures
M.N. Mbugua +3 more
doaj
Current Research in Green and Sustainable ChemistryThis study focuses on the synthesis of pyrano[2,3-d]pyrimidine structures through a one-pot process without the use of metals. The method employs Knoevenagel-Michael cyclocondensation and utilizes a low-cost, reusable catalyst, 2-aminopyridine.
Farzaneh Mohamadpour
doaj +1 more source
Efficient Synthesis of 2-Aminopyridine Derivatives: Antibacterial Activity Assessment and Molecular Docking Studies. [PDF]
Molecules, 2022 Kibou Z +6 more
europepmc +1 more source