Palladium-catalysed amination of electron-deficient or relatively-rich benzo[b]thienylbromides: preliminary studies of antimicrobial activity and SARs [PDF]
, 2004 Several diarylamines in the benzo[b]thiophene series were prepared by palladium catalyzed amination of ethyl 3-bromobenzo[b]thien-2-yl carboxylate with anilines and 5-aminoindole, in good to high yields using Pd(OAc)2, BINAP, Cs2CO3 in toluene.
Barbosa, Sandra +6 more
core +2 more sources
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Pyridinium N-2´-pyridylaminide: radical cyclization for the synthesis of benzonaphthyridine derivatives [PDF]
, 2007 The synthesis of benzonaphthyridine derivatives that incorporate a 2-aminopyridine moiety can be performed by intramolecular radical pyridylation of the appropriate substrates, obtained from pyridinium N-2¿-pyridylaminide, using TTMSS and AIBN.Financial ...
Burgos García, Carolina +3 more
core +3 more sources
Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety
Advanced Science, EarlyView.This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi +15 more
wiley +1 more source
Diphenyl[2-(2-pyridylaminomethyl)phenyl]phosphine oxide
Acta Crystallographica Section E, 2010 The title compound, C24H21N2OP, was obtained by reacting 2-aminopyridine and 2-(diphenylphosphinyl)benzaldehyde in ethanol. It crystallizes with two crystallographically independent molecules in the asymmetric unit.
Simón Hernández-Ortega +2 more
doaj +1 more source
Crystals, 2023 Thirty-four binary systems of nitrofurantoin with pyridine derivatives were analyzed by combining virtual (molecular complementarity prediction and hydrogen bond propensity calculations) and experimental (liquid-assisted grinding) screening methods.
Alex N. Manin +5 more
doaj +1 more source
Hydrogen bond based noncovalent association in the semi-fluorous solvent perfluorobutyl-methyl ether: Host-host and host-guest association of the host 1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluoro-decyl)-3-pyridin-2-yl-urea [PDF]
, 2013 A fluorous pyridyl-urea, 1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl)-3-pyridin-2-yl-urea, was prepared to act as a host and analyzed by 1H NMR inCD2Cl2 and perfluorobutyl-methyl ether (HFE7100).
McGowan, Candace
core +1 more source
Closed-shell ring coupled cluster doubles theory with range separation applied on weak intermolecular interactions [PDF]
, 2011 We explore different variants of the random phase approximation (RPA) to the correlation energy derived from closed-shell ring-diagram approximations to coupled cluster doubles theory.
Angyán, János G. +4 more
core +2 more sources
Advanced Science, EarlyView.A brain‐adhesive sensor (B‐Sensor) was developed by integrating a self‐healing biodegradable elastomer, a tissue‐adhesive hydrogel, and molybdenum electrodes. The B‐Sensor adheres to brain tissue, conforms to cortical curvatures, and maintains stable electrical performance over the intended period for reliable recording of spatiotemporal brain activity
Heewon Choi +8 more
wiley +1 more source
2-(3-Aminopyridinium-1-yl)-3-carboxypropanoate monohydrate
Acta Crystallographica Section E, 2012 The title compound, C9H10N2O4·H2O, was obtained as a zwitterion derived from the nucleophilic attack of 3-aminopyridine on the fumaric α,β-system. Within the molecule, the aminopyridine moiety and the carboxylate and carboxylic
José J. Campos-Gaxiola +4 more
doaj +1 more source