Results 161 to 170 of about 97,768,097 (202)

A new, practical synthesis of 2-methoxyestradiols

Steroids, 2002
An efficient and practical approach to synthesize moderate to large amounts of 2-methoxyestradiol (2-ME2) is described. The key step in the synthesis is the regioselective introduction of an acetyl group at the C-2 position of estradiol using a zirconium tetrachloride mediated Fries rearrangement carried out on estradiol diacetate.
Pemmaraju N, Rao, James W, Cessac
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2-Hydroxyestradiol Is a Prodrug of 2-Methoxyestradiol

The Journal of Pharmacology and Experimental Therapeutics, 2004
Previous in vivo studies indicate that 2-hydroxyestradiol (2OHE) attenuates cardiovascular and renal diseases. In vitro studies suggest that the biological effects of 2OHE are mediated by 2-methoxyestradiol (2MEOE) after methylation of 2OHE by catechol-O-methyltransferase (COMT). This study tested the hypothesis that in vivo 2OHE is a prodrug of 2MEOE.
Lefteris C, Zacharia, Claude A, Piché, Robert M, Fielding, Kathleen M, Holland, S Dean, Allison, Raghvendra K, Dubey, Edwin K, Jackson   +6 more
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Effects of 2-methoxyestradiol on endometrial carcinoma xenografts

Journal of Cancer Research and Clinical Oncology, 2006
We have previously demonstrated that 2-methoxyestradiol (2-ME) inhibits the growth of human endometrial cancer HEC-1-A and RL-95-2 cells in vitro. In this study, we examined the effects of 2-ME on human endometrial carcinoma in severe combined immune deficient (SCID) mice.
Li, Li, Fengling, Yu, Xiaohua, Wu, Jianxin, Cheng, Ulf, Ulmsten, Xin, Fu   +5 more
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2-Methoxyestradiol Does Not Inhibit Superoxide Dismutase

Archives of Biochemistry and Biophysics, 2001
It has been reported in the literature that the endogenous estrogen metabolite 2-methoxyestradiol (2-ME) inhibits both manganese and copper,zinc superoxide dismutases (Mn and Cu,Zn SODs) and that this mechanism is responsible for 2-ME's ability to kill cancer cells. In fact, as demonstrated using several SOD assays including pulse radiolysis, 2-ME does
R, Kachadourian, S I, Liochev, D E, Cabelli, M N, Patel, I, Fridovich, B J, Day   +5 more
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2-Methoxyestradiol and multidrug resistance: can 2-methoxyestradiol chemosensitize resistant breast cancer cells?

Breast Cancer Research and Treatment, 2008
2-Methoxyestradiol (2ME), a natural derivative of estradiol, is currently evaluated in clinical trials for breast cancer. The current study aims to evaluate the modulatory effects of 2ME on regulation of multidrug resistance (MDR) in doxorubicin (Dox) resistant breast cancer cells (MCF-7/Dox) and its underlying mechanisms.
Samar S, Azab, Salama A, Salama, Ashraf B, Abdel-Naim, Amani E, Khalifa, Ebtehal, El-Demerdash, Ayman, Al-Hendy   +5 more
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Colchicine and 2-methoxyestradiol Inhibit Human Angiogenesis

Journal of Surgical Research, 2005
Angiogenesis is a critical determinant of tumor growth and the development of metastases. Tubulin inhibitors have been shown to be effective inhibitors of angiogenesis. We hypothesized that colchicine, a well-know tubulin inhibitor and 2-methoxyestradiol (2 MeOH), a novel tubulin inhibitor, would limit the initiation of a human angiogenic response and ...
S J, Stafford, J, Schwimer, C T, Anthony, J L, Thomson, Y Z, Wang, E A, Woltering   +5 more
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2-Methoxyestradiol as a Potential Cytostatic Drug in Gliomas?

Anti-Cancer Agents in Medicinal Chemistry, 2009
Gliomas of astrocytic origin show only a limited chemotherapy response. Chemoresistance is most pronounced in glioblastoma multiforme, the most common and most malignant glioma, with median survival times not much longer than one year. Failure of chemotherapy partly relies on protective mechanisms against the commonly used DNA alkylating agents ...
E, Kirches, M, Warich-Kirches
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Cytogenetic Chromosomal Preparations Using 2-Methoxyestradiol

Cancer Genetics and Cytogenetics, 1998
The antimitotic drug 2-methoxyestradiol is an end metabolite of catechol estrogens. In vivo, it arrests cells in mitosis by interfering with the dynamics of the mitotic spindle without disrupting tubulin formation. It has a mitotic index similar to that of Colcemid in different cell lines.
H, Attalla, S, Knuutila, T P, Mäkelä, L C, Andersson, H, Adlercreutz   +4 more
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2‐methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts

Journal of Cellular Biochemistry, 2006
Abstract2‐Methoxyestradiol (2‐ME), a naturally occurring metabolite of 17β‐estradiol, is highly cytotoxic to a wide range of tumor cells but is harmless to most normal cells. However, 2‐ME prevented bone loss in ovariectomized rats, suggesting it inhibits bone resorption.
A, Maran, G, Gorny, M J, Oursler, M, Zhang, K L, Shogren, M J, Yaszemski, R T, Turner   +6 more
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Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol

Biochemical and Biophysical Research Communications, 2004
2-Methoxyestradiol (2ME2), a naturally occurring metabolite of estradiol, is known to have antiproliferative, antiangiogenic, and proapoptotic activity. Mechanistically, 2ME2 has been shown to downregulate hypoxia-inducible factor 1alpha (HIF1alpha) and to induce apoptosis in tumour cells by generating reactive oxygen species (ROS).
Hagen, Thilo, D'Amico, Gabriela, Quintero, Marisol, Palacios-Callender, Miriam, Hollis, Veronica, Lam, Francis, Moncada, Salvador   +6 more
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