Results 41 to 50 of about 993,691 (269)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Assessment of human expertise and movement kinematics in first-person shooter games
Frontiers in Human Neuroscience, 2022 In contrast to traditional professional sports, there are few standardized metrics in professional esports (competitive multiplayer video games) for assessing a player's skill and ability.
Ian Donovan +5 more
doaj +1 more source
A 2-person game on a polyhedral set of connected strategies
Computers & Mathematics with Applications, 1997 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
A 2-Person Game Decomposing 2-Manifolds
Two players play a game by alternately splitting a surface of a compact $2$-manifold along a simple closed curve that is not null-homotopic and attaching disks to the resulting boundary; the last player who can move wins. Starting from an orientable surface, the $G$-series is $01\dot{2}\dot{0}$ according to increasing genus.
Berman, David R., Leonard, Lee O.
openaire +2 more sources
A game interpretation of the Neumann problem for fully nonlinear parabolic and elliptic equations
, 2012 We provide a deterministic-control-based interpretation for a broad class of fully nonlinear parabolic and elliptic PDEs with continuous Neumann boundary conditions in a smooth domain.
Daniel, Jean-Paul
core +5 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
The Sources and Educational Consequences of Anthropological Reductionism
Paedagogia Christiana, 2012 Reductionist tendencies mean the exclusion of important elements from the conception of man. Theoretical (philosophical) mistakes lead to serious consequences in pedagogy and have destructive influence on educational practices.
Witold Starnawski
doaj +1 more source