Results 51 to 60 of about 990,944 (268)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Advances in Zero-Sum Dynamic Games [PDF]

, 2015
International audienceThe survey presents recent results in the theory of two-person zero-sum repeated games and their connections with differential and continuous-time games.
Agarwal, As Soulaimani, Assoulamani, Aumann, Bardi, Bardi, Bewley, Bewley, Bich, Blackwell, Blackwell, Blackwell, Bolte, Brézis, Buckdahn, Buckdahn, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Cardaliaguet, Coulomb, Coulomb, Coulomb, Coulomb, Coulomb, Coulomb, Crandall, De Meyer, De Meyer, De Meyer, De Meyer, De Meyer, De Meyer, De Meyer, Dynkin, E., Evans, Everett, Forges, Friedman, Gale, Gensbittel, Gensbittel, Gensbittel, Gensbittel, Gensbittel, Grün, Grün, Guo, Guo, Heuer, Heuer, Hörner, Kohlberg, Kohlberg, Kohlberg, Kohn, Krasovskii, Krausz, Laraki, Laraki, Laraki, Laraki, Laraki, Laraki, Laraki, Laraki, Lehrer, Lehrer, Lehrer, Lepeltier, Levy, Maitra, Maitra, Maitra, Maitra, Maitra, Martin, Martin, Mertens, Mertens, Mertens, Mertens, Mertens, Mertens, Mertens, Mertens, Mertens, Mertens, Mertens, Mertens, Milman, Monderer, Neveu, Neyman, Neyman, Neyman, Neyman, Neyman, Neyman, Neyman, Neyman, Oliu-Barton, Perchet, Perchet, Perchet, Perchet, Perchet, Quincampoix, Radzik, Renault, Renault, Renault, Renault, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Scarf, Shapley, Shmaya, Shmaya, Solan, Solan, Solan, Sorin, Sorin, Sorin, Sorin, Sorin, Sorin, Sorin, Sorin, Sorin, Sorin, Souganidis, Souganidis, Souquieré, Spinat, van den Dries, Vieille, Vieille, Vigeral, Vigeral, Zachrisson, Zamir, Zamir   +159 more
core   +3 more sources

Outcomes, Measurement Instruments, and Their Validity Evidence in Randomized Controlled Trials on Virtual, Augmented, and Mixed Reality in Undergraduate Medical Education: Systematic Mapping Review

JMIR Serious Games, 2022
BackgroundExtended reality, which encompasses virtual reality (VR), augmented reality (AR), and mixed reality (MR), is increasingly used in medical education. Studies assessing the effectiveness of these new educational modalities
Lorainne Tudor Car, Bhone Myint Kyaw, Andrew Teo, Tatiana Erlikh Fox, Sunitha Vimalesvaran, Christian Apfelbacher, Sandra Kemp, Niels Chavannes   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Games where you can play optimally without any memory [PDF]

, 2005
International audienceReactive systems are often modelled as two person antagonistic games where one player represents the system while his adversary represents the environment.
A. Bouquet, A. Ehrenfeucht, E. Grädel, E.A. Emerson, H. Gimbert, H. Gimbert, L. de Alfaro, L. de Alfaro, L.S. Shapley, M.J. Osborne, T. Cachat   +10 more
core   +3 more sources

The Sources and Educational Consequences of Anthropological Reductionism

Paedagogia Christiana, 2012
Reductionist tendencies mean the exclusion of important elements from the conception of man. Theoretical (philosophical) mistakes lead to serious consequences in pedagogy and have destructive influence on educational practices.
Witold Starnawski
doaj   +1 more source

A 2-Person Game Decomposing 2-Manifolds

Two players play a game by alternately splitting a surface of a compact $2$-manifold along a simple closed curve that is not null-homotopic and attaching disks to the resulting boundary; the last player who can move wins. Starting from an orientable surface, the $G$-series is $01\dot{2}\dot{0}$ according to increasing genus.
Berman, David R., Leonard, Lee O.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Value in mixed strategies for zero-sum stochastic differential games without Isaacs condition [PDF]

, 2014
In the present work, we consider 2-person zero-sum stochastic differential games with a nonlinear pay-off functional which is defined through a backward stochastic differential equation.
Buckdahn, Rainer, Li, Juan, Quincampoix, Marc   +2 more
core   +3 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source