Results 61 to 70 of about 24,429,528 (155)

Synthesis of Some New Enaminoketones, Analogous of Milrinone, 4,Pyrones and Related 4-Pyridones [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1996
Synthesis of 4-(N,N- dimethylamino)-3-aryl-3-butene-2-one, ethyl-5-aryl-4-oxo-4H-pyran-2-carboxylate, ethyl-5-aryl-4-pyridones-2-carboxylate and 5-aryl-3-cyano-5-methyl-2-pyridones (aryl=3-thienyl, 2-furyl) are described.
Aziz Shahrisa, Salar Hemmati
doaj  

Ultrafast Decay Dynamics of the 2¹ππ* Electronic State of N‑Methyl-2-pyridone

The ultrafast decay dynamics of N-methyl-2-pyridone upon excitation in the near-ultraviolet range of 261.5–227.9 nm is investigated using the femtosecond time-resolved photoelectron spectroscopy method.
Wenping Wu (121781), Dongyuan Yang (8968340), Baihui Feng (17425266), Zhigang He (544691), Guorong Wu (307379), Xueming Yang (593735)   +5 more
core   +1 more source

Synthesis, Characterization, and Biological Assessment of 2‐Methoxynicotinonitrile Derivatives

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
We report the synthesis of new 2‐methoxy‐3‐cyanopyridine derivatives via the nucleophilic aromatic substitution pathway, along with their crystal structure determination and preliminary biological evaluation. The new synthetic conversion described here demonstrates a practical method of preparing structurally diverse 2‐methoxy‐3‐cyanopyridines and ...
Eman Sulaiman, Eman Al‐Masri, Maram B. Alhawarri, Mohammad M. Ibrahim, Mahmoud Al‐Refai, Basem F. Ali, Ali Shuaib   +6 more
wiley   +1 more source

catena-Poly[[[(2-pyridone-kappa O)silver(I)]l-mu-2-pyridone-kappa O-2/O] hexafluoridophosphate]

, 2010
The asymmetric unit of the polymeric title salt, {[Ag(C5H5-NO)(2)]PF6}(n), comprises an Ag I cation (located on a twofold axis), two 2-pyridone ligands (with distinct coordination modes), and half a PF6- anion (situated on a centre of inversion).
Tiekink, E.R.T., Miller, T., Arman, H.D.
core   +2 more sources

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1278-1290, September 2026.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Avoiding pitfalls when modelling ligands in macromolecular crystallography

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1016-1029, September 2026.
Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart, Andrew Sharff, Claus Flensburg, Clemens Vonrhein, Gérard Bricogne   +4 more
wiley   +1 more source

Crystal structure of N-[6-amino-5-(benzo[d]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C21H17N5O3S3·C3H7NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°.
Rasha A. Azzam, Galal H. Elgemeie, Rasha E. Elsayed, Peter G. Jones   +3 more
doaj   +1 more source

Identification of New Anti‐Trypanosoma brucei Leads: An Integrated CRK12‐Guided Virtual Screen With Experimental Validation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Qin Li, Chenggong Fu, Jiayi Luo, Qianqian Zhang, Lingling Wang, Xiaomeng Liu, Jiayue Qiu, Xiaoqing Gong, Henry H. Y. Tong, Xiaojun Yao, Dehua Lai, Huanxiang Liu   +11 more
wiley   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

SYNTHETIC ROUTES AND NATURAL SOURCES OF 2-PYRIDONE DERIVATIVES AND THEIR PHARMACOLOGICAL ACTIVITY [PDF]

, 2017
Objective: 2-pyridone is a well-known heterocyclic ring having significant biological and medical application. The molecular structures and various activities of 2-pyridone derivatives as well as their syntheses and natural occurrence are analyzed and ...
MISHRA, PREM SHANKAR, V, Ravichandiran, M, Vijey Aanandhi   +2 more
core   +3 more sources