Results 81 to 90 of about 42,888,361 (250)

Ester-Amide Exchange Reactions Using 2-Pyridone derivatives as Tautomeric Catalysts

The application of 2-pyridone as a tautomeric catalyst for ester-amide exchange reactions was investigated. This compound was found to be most effective at accelerating these reactions when 4-nitrophenyl acetate was used as an acylating agent in toluene.
Misao, Yotsuji, Ayumi, Imayoshi, Kanako, Mihara, Kazunori, Tsubaki   +3 more
core   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, Volume 183, Issue 10, Page 2219-2235, May 2026.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

SYNTHETIC ROUTES AND NATURAL SOURCES OF 2-PYRIDONE DERIVATIVES AND THEIR PHARMACOLOGICAL ACTIVITY

, 2017
Objective: 2-pyridone is a well-known heterocyclic ring having significant biological and medical application. The molecular structures and various activities of 2-pyridone derivatives as well as their syntheses and natural occurrence are analyzed and ...
MISHRA, PREM SHANKAR, V, Ravichandiran, M, Vijey Aanandhi   +2 more
core   +2 more sources

Crystal structure of N-[6-amino-5-(benzo[d]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C21H17N5O3S3·C3H7NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°.
Rasha A. Azzam, Galal H. Elgemeie, Rasha E. Elsayed, Peter G. Jones   +3 more
doaj   +1 more source

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐nicotinamide mononucleotide (β‐NMN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including an evaluation of the safety of its use in food supplements as a source of niacin ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Ursula Gundert‐Remy, Francesca Marcon, Harry J. McArdle, Monika Neuhäuser‐Berthold, Miguel Prieto Maradona, Alexandros Siskos, Matthew Wright, Elisa Beneventi, Annamaria Rossi, Maura Magani, Karen Ildico Hirsch‐Ernst   +28 more
wiley   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Non‐redox Lewis Acids Supported Pd‐Catalyzed C—C /C—H Activation and Accession to Produce Pharmaceutical Intermediates

ChemistryOpen, Volume 15, Issue 4, April 2026.
Palladium is a simple and versatile redox‐active metal that plays a crucial role in the oxidation reactions for organic synthesis and production of pharmaceutical intermediates. Notably, there has been significant progress with Lewis acids (LAs), which are non‐redox metal ions promoting Pd(II)‐catalyzed oxidation via C—H and C—C bond activation.
Ahmed M. Senan, Senem Akkoc, A. M. Abdulkarem, Sadeq K. Alhag   +3 more
wiley   +1 more source

Reaction-Phase-Selective Inter- and Intramolecular Photochemical Reaction of 2-Pyridone Derivatives

, 2016
Phase-selective photochemical reaction of 2-pyridone derivatives was examined. Irradiation of 1 in benzene mainly gave rearrangement products 2. However, intermolecular [4 + 4] photocycloaddition proceeded quantitatively in the solid state, affording ...
Takao Noguchi (552298), Makoto Yamamoto (55964), Keiki Kishikawa (1591579), Hyuma Masu (1591576), Kentaro Yamaguchi (1415581), Shigeo Kohmoto (1591582)   +5 more
core   +3 more sources

catena-Poly[[(nitrato-κ2O,O′)silver(I)]-μ3-4-pyridone-κ3O:O:O]

Acta Crystallographica Section E, 2009
In the title complex, [Ag(NO3)(C5H5NO)]n, the AgI atom is coordinated by two O atoms from two different 4-pyridone ligands and two O atoms from one nitrate anion, displaying a nearly planar coordination geometry.
Xian-Ge Wu, Jun-Xia Xiao, Liang Qin
doaj   +1 more source

Synthesis, structure and solvatochromic properties of some novel 5-arylazo-6-hydroxy-4- (4-methoxyphenyl)-3-cyano-2-pyridone dyes: Hydrazone-azo tautomeric analysis

, 2015
A series of eleven new 5-arylazo-6-hydroxy-4-(4-methoxyphenyl)-3-cyano-2-pyridone dyes was synthesized and their absorption spectra were recorded in twenty solvents in the range 300–600 nm.
Adel S. Alimmari, B. Božić, D. Mijin, A. Marinković, Nataša Valentić, G. Uscumlic   +5 more
semanticscholar   +1 more source